Modeling the metabolic profile of Mytilus edulis reveals molecular signatures linked to gonadal development, sex and environmental site.
Modeling the metabolic profile of Mytilus edulis reveals molecular signatures linked to gonadal development, sex and environmental site.
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DOI：
10.1038/s41598-021-90494-y
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发表时间：
2021-06-18
影响因子：
4.6
通讯作者：
Falciani F
中科院分区：
文献类型：
--
作者：
Kronberg J;Byrne JJ;Jansen J;Antczak P;Hines A;Bignell J;Katsiadaki I;Viant MR;Falciani F
监测水生环境中的人为化学品，包括其对水生生物的潜在影响，对于保护水下生命这一关键的可持续发展目标十分重要。在监测有关化学品浓度的同时，哨兵物种往往被用来调查污染物的生物影响。其中，贻贝等双壳类软体动物是滤食性和固着的，因此是测量局部污染的极好模型系统。研究了紫贻贝（Mytilus edulis）在不同环境中的代谢状态与生理的关系。我们开发了一个计算模型的基础上参考网站（相对未受污染）和代谢物的相对浓度与关键生理指标和环境参数的季节动态集成。该模型的分析表明，代谢物水平的变化在一个年度周期中的水温的影响，并与性腺发育。这项工作支持了数据驱动生物学的重要性及其在环境监测中的潜力。
The monitoring of anthropogenic chemicals in the aquatic environment including their potential effects on aquatic organisms, is important for protecting life under water, a key sustainable development goal. In parallel with monitoring the concentrations of chemicals of concern, sentinel species are often used to investigate the biological effects of contaminants. Among these, bivalve molluscs such as mussels are filter-feeding and sessile, hence an excellent model system for measuring localized pollution. This study investigates the relationship between the metabolic state of the blue mussel (Mytilus edulis) and its physiology in different environments. We developed a computational model based on a reference site (relatively unpolluted) and integrated seasonal dynamics of metabolite relative concentrations with key physiological indicators and environmental parameters. The analysis of the model revealed that changes in metabolite levels during an annual cycle are influenced by water temperature and are linked to gonadal development. This work supports the importance of data-driven biology and its potential in environmental monitoring.
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影响因子：
11.4
作者：
Ellis, Robert P.;Spicer, John I.;Widdicombe, Steve
通讯作者：
Widdicombe, Steve
影响因子：
8.9
作者：
Hellou, J;Law, RJ
通讯作者：
Law, RJ
DOI：
10.1073/pnas.1111076108
发表时间：
2011-09-20
影响因子：
11.1
作者：
Connor, Kwasi M.;Gracey, Andrew Y.
通讯作者：
Gracey, Andrew Y.
影响因子：
5.8
作者：
de los Rios, Ana;Juanes, Jose A.;Cajaraville, Miren P.
通讯作者：
Cajaraville, Miren P.
影响因子：
3.7
作者：
Dheilly NM;Lelong C;Huvet A;Kellner K;Dubos MP;Riviere G;Boudry P;Favrel P
通讯作者：
Favrel P