Cocaine use associated gut permeability and microbial translocation in people living with HIV in the Miami Adult Study on HIV (MASH) cohort.
Cocaine use associated gut permeability and microbial translocation in people living with HIV in the Miami Adult Study on HIV (MASH) cohort.
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DOI：
10.1371/journal.pone.0275675
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Baum, Marianna K.
中科院分区：
文献类型：
--
作者：
Hernandez, Jacqueline;Tamargo, Javier A.;Martinez, Sabrina Sales;Martin, Haley R.;Campa, Adriana;Sekaly, Rafick-Pierre;Bordi, Rebeka;Sherman, Kenneth E.;Rouster, Susan D.;Meeds, Heidi L.;Khalsa, Jag H.;Mandler, Raul N.;Lai, Shenghan;Baum, Marianna K.
确定可卡因使用是否影响肠道通透性，促进使用有效抗逆转录病毒疗法（ART）的艾滋病毒感染者（PLWH）的微生物易位和免疫激活。来自迈阿密成人HIV研究（MASH）队列的100例PLWH（ART ≥6个月，HIV-RNA <200拷贝/mL）的横断面分析。通过自我报告、尿液筛查和血液苯甲酰芽子碱（BE）评估可卡因使用情况。采集血液样本以评估肠道通透性（肠脂肪酸结合蛋白，I-FABP）、微生物易位（脂多糖，LPS）、免疫活化（sCD 14、sCD 27和sCD 163）和炎症标志物（hs-CRP、TNF-α和IL-6）。采用多元线性回归模型分析可卡因使用的关系。共对37名可卡因使用者和63名可卡因非使用者进行了评价。可卡因使用者的I-FABP（7.92±0.35 vs.7.69 ±0.56 pg/mL，P = 0.029）和LPS（0.76±0.24 vs.0.54 ±0.27 EU/mL，P<0.001）水平高于可卡因非使用者。在调整协变量后，辅酶A的使用也与LPS（P<0.001）、I-FABP（P = 0.033）和sCD 163（P = 0.010）水平相关。服用避孕药者的LPS水平比不服用避孕药者高5.15倍（OR：5.1595% CI：1.89-13.9; P<0.001）。血液BE水平与LPS（rho = 0.276，P = 0.028）、sCD 14（rho = 0.274，P = 0.031）和sCD 163（rho = 0.250，P = 0.049）直接相关。在病毒抑制的PLWH中，辅酶A的使用与肠道通透性、微生物易位和免疫激活标志物相关。减少可卡因的使用可以防止PLWH中进一步的胃肠道损伤和免疫激活。
Determine if cocaine use impacts gut permeability, promotes microbial translocation and immune activation in people living with HIV (PLWH) using effective antiretroviral therapy (ART). Cross-sectional analysis of 100 PLWH (ART ≥6 months, HIV-RNA <200 copies/mL) from the Miami Adult Studies on HIV (MASH) cohort. Cocaine use was assessed by self-report, urine screen, and blood benzoylecgonine (BE). Blood samples were collected to assess gut permeability (intestinal fatty acid-binding protein, I-FABP), microbial translocation (lipopolysaccharide, LPS), immune activation (sCD14, sCD27, and sCD163) and markers of inflammation (hs-CRP, TNF-α and IL-6). Multiple linear regression models were used to analyze the relationships of cocaine use. A total of 37 cocaine users and 63 cocaine non-users were evaluated. Cocaine users had higher levels of I-FABP (7.92±0.35 vs. 7.69±0.56 pg/mL, P = 0.029) and LPS (0.76±0.24 vs. 0.54±0.27 EU/mL, P<0.001) than cocaine non-users. Cocaine use was also associated with the levels of LPS (P<0.001), I-FABP (P = 0.033), and sCD163 (P = 0.010) after adjusting for covariates. Cocaine users had 5.15 times higher odds to exhibit higher LPS levels than non-users (OR: 5.15 95% CI: 1.89–13.9; P<0.001). Blood levels of BE were directly correlated with LPS (rho = 0.276, P = 0.028), sCD14 (rho = 0.274, P = 0.031), and sCD163 (rho = 0.250, P = 0.049). Cocaine use was associated with markers of gut permeability, microbial translocation, and immune activation in virally suppressed PLWH. Mitigation of cocaine use may prevent further gastrointestinal damage and immune activation in PLWH.
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影响因子：
2.4
作者：
Bischoff SC;Barbara G;Buurman W;Ockhuizen T;Schulzke JD;Serino M;Tilg H;Watson A;Wells JM
通讯作者：
Wells JM
影响因子：
3.8
作者：
Canani, RB;De Marco, G;Guarino, A
通讯作者：
Guarino, A
影响因子：
4.2
作者：
Cheru, Lediya T.;Park, Elli A.;Lo, Janet
通讯作者：
Lo, Janet
影响因子：
1.5
作者：
Baum, Marianna K.;Rafie, Carlin;Campa, Adriana
通讯作者：
Campa, Adriana
DOI：
10.1161/atvbaha.116.307985
发表时间：
2016-10-01
影响因子：
8.7
作者：
Lucas, Gregory M.;Atta, Mohamed G.;Stein, James H.
通讯作者：
Stein, James H.