Vessel arterial-venous plasticity in adult neovascularization.
Vessel arterial-venous plasticity in adult neovascularization.
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DOI：
10.1371/journal.pone.0027332
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Hoying JB
中科院分区：
文献类型：
--
作者：
Nunes SS;Rekapally H;Chang CC;Hoying JB
适当的动脉和静脉规格是功能性血管网络的标志。虽然动静脉特性是在胚胎发育过程中通过基因预先决定的，但尚不清楚在成人新生血管形成中是否会发生类似的预先指定。我们的目标是确定成人新生血管形成中的血管动静脉规范是否是由原始血管的身份预先确定的。我们通过植入来自小鼠和大鼠的分离的动脉特征微血管并评估由此产生的新形成的脉管系统的特征结果来评估新血管形成过程中的特征规范。这些具有动脉特性的微血管自发地形成了典型的、灌注的微循环，由成熟微脉管系统固有的全部微血管类型组成。微血管特性的变化发生在血管生成过程中，新血管表现出与 EphrinB2 磷酸化减少相关的模糊动静脉表型。我们的研究结果表明，成人新生血管形成中的微血管动静脉特性不一定是预先确定的，并且成人微血管在新生血管形成过程中表现出相当水平的表型可塑性。此外，我们还发现，动脉血管也具有发生血管生成的潜力。
Proper arterial and venous specification is a hallmark of functional vascular networks. While arterial-venous identity is genetically pre-determined during embryo development, it is unknown whether an analogous pre-specification occurs in adult neovascularization. Our goal is to determine whether vessel arterial-venous specification in adult neovascularization is pre-determined by the identity of the originating vessels. We assessed identity specification during neovascularization by implanting isolated microvessels of arterial identity from both mice and rats and assessing the identity outcomes of the resulting, newly formed vasculature. These microvessels of arterial identity spontaneously formed a stereotypical, perfused microcirculation comprised of the full complement of microvessel types intrinsic to a mature microvasculature. Changes in microvessel identity occurred during sprouting angiogenesis, with neovessels displaying an ambiguous arterial-venous phenotype associated with reduced EphrinB2 phosphorylation. Our findings indicate that microvessel arterial-venous identity in adult neovascularization is not necessarily pre-determined and that adult microvessels display a considerable level of phenotypic plasticity during neovascularization. In addition, we show that vessels of arterial identity also hold the potential to undergo sprouting angiogenesis.
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影响因子：
37.8
作者：
Hayashi, S;Asahara, T;Losordo, DW
通讯作者：
Losordo, DW
影响因子：
16
作者：
Gerety, SS;Wang, HU;Anderson, DJ
通讯作者：
Anderson, DJ
DOI：
10.1007/978-3-540-78281-0_7
发表时间：
2010-01-01
期刊：
ANGIOGENESIS INHIBITION
影响因子：
--
作者：
Hellberg, Carina;Ostman, Arne;Heldin, C. -H.
通讯作者：
Heldin, C. -H.
缺乏周细胞会导致内皮增生和异常血管形态发生。
影响因子：
7.8
作者：
Hellstrom, M;Gerhardt, H;Kalen, M;Li, X;Eriksson, U;Wolburg, H;Betsholtz, C
通讯作者：
Betsholtz, C
影响因子：
3.6
作者：
dela Paz, Nathaniel G.;D'Amore, Patricia A.
通讯作者：
D'Amore, Patricia A.