Arterial versus venous endothelial cells.

Arterial versus venous endothelial cells.
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DOI:
10.1007/s00441-008-0706-5
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发表时间:
2009-01
影响因子:
3.6
通讯作者:
D'Amore, Patricia A.
D'Amore, Patricia A.
中科院分区:
生物学3区
文献类型:
--
作者:
dela Paz, Nathaniel G.;D'Amore, Patricia A.

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血管内皮细胞(EC)形成所有血管的内壁,从最大的动脉和静脉,即主动脉和腔静脉,到连接动脉和静脉系统的毛细血管。由于心血管系统的这两个主要传导系统在功能上有所不同,因此动脉和静脉的物理构成(包括排列在其腔内的 EC)也不同也就不足为奇了。尽管很少有人认为局部环境导致了动脉和静脉之间的差异,但最近的证据表明,动脉和静脉特性的规范很大程度上是由基因决定的。
Vascular endothelial cells (ECs) form the inner lining of all blood vessels from the largest artery and veins, viz., the aorta and venae cavae, respectively, to the capillaries that connect the arterial and venous systems. Because these two major conducting systems of the cardiovasculature differ functionally, it is not surprising that the physical makeup of arteries and veins, including the ECs that line their lumina, are also distinct. Although few would argue that the local environment contributes to the differences between arteries and veins, recent evidence has shown that the specification of arterial and venous identity is largely genetically determined.
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