Iron-Palladium Decorated Carbon Nanotubes Achieve Radiosensitization via Reactive Oxygen Species Burst.
Iron-Palladium Decorated Carbon Nanotubes Achieve Radiosensitization via Reactive Oxygen Species Burst.
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DOI：
10.3389/fbioe.2021.683363
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发表时间：
2021
影响因子：
5.7
通讯作者：
Bao Z
中科院分区：
文献类型：
--
作者：
Yang S;Yang Y;Yang Y;Zhao X;Wang Q;Li B;Dong L;Tian R;Bao Z
放射治疗是临床上推荐的一种癌症治疗方法。然而，由于癌细胞的DNA修复，其对治疗性辐射具有抗性。本工作以具有中空结构和高比表面积等独特物理性能的单壁碳纳米管为载体，制备了铁钯修饰碳纳米管（FePd@CNTs）。一方面，FePd纳米粒子具有显著的放射增敏作用。另一方面，碳纳米管在穿过生物屏障方面提供更高的效率，诱导FePd纳米颗粒在肿瘤组织内的积累和保留。为了验证FePd@CNTs的放射增敏作用，进行了体外和体内实验。实验结果表明，FePd@CNTs的放射增敏效果明显优于FePd纳米颗粒，且在体内的蓄积量明显高于FePd纳米颗粒，表明FePd@CNTs具有潜在的放射增敏作用。
Radiotherapy is recommended as a modality for cancer treatment in clinic. However, cancerous cells were resistant to therapeutic irradiation due to its DNA repair. In this work, single-walled carbon nanotubes with unique physical properties of hollow structures and high specific surface area were introduced as carrier for iron-palladium (FePd) to obtain iron-palladium decorated carbon nanotubes (FePd@CNTs). On one hand, FePd nanoparticles possess significant ability in radiosensitization as previously reported. On the other hand, carbon nanotubes offer higher efficiency in crossing biological barriers, inducing the accumulation and retention of FePd nanoparticles within tumor tissue. In order to verify the radiosensitization effect of FePd@CNTs, both in vitro and in vivo experiments were conducted. These experiments showed that the FePd@CNTs exhibited remarkably better radiosensitization effect and more obvious accumulation than FePd NPs, suggesting a potential of FePd@CNTs in radiosensitization.
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DOI：
10.1038/nrclinonc.2015.120
发表时间：
2015-09
期刊：
Nature reviews. Clinical oncology
影响因子：
--
作者：
Schaue D;McBride WH
通讯作者：
McBride WH
影响因子：
14
作者：
Deng, Junjie;Xu, Shandong;Su, Ming
通讯作者：
Su, Ming
可生物降解的中空介孔有机二氧化硅纳米治疗剂用于温和热疗诱导气泡增强氧敏放射治疗
影响因子：
17.1
作者：
Lu, Nan;Fan, Wenpei;Chen, Xiaoyuan
通讯作者：
Chen, Xiaoyuan
影响因子：
9.3
作者：
Bhide SA;Nutting CM
通讯作者：
Nutting CM
影响因子：
4
作者：
Balkwill, Frances R.;Capasso, Melania;Hagemann, Thorsten
通讯作者：
Hagemann, Thorsten