Structural probes in quadruplex nucleic acid structure determination by NMR.
Structural probes in quadruplex nucleic acid structure determination by NMR.
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双链核酸结构中的结构探针通过NMR测定。
DOI:
10.3390/molecules171113073
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发表时间:
2012-11-05
期刊:
影响因子:
--
通讯作者:
Webba da Silva M
中科院分区:
文献类型:
--
作者:
Karsisiotis AI;Webba da Silva M
Traditionally, isotope-labelled DNA and RNA have been fundamental to nucleic acid structural studies by NMR. Four-stranded nucleic acid architectures studies increasingly benefit from a plethora of nucleotide conjugates for resonance assignments, the identification of hydrogen bond alignments, and improving the population of preferred species within equilibria. In this paper, we review their use for these purposes. Most importantly we identify reasons for the failure of some modifications to result in quadruplex formation.
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影响因子:
14.9
作者:
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通讯作者:
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DOI:
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发表时间:
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期刊:
NATURE STRUCTURAL BIOLOGY
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