Lipidomics analysis revealed the phospholipid compositional changes in muscle by chronic exercise and high-fat diet.
Lipidomics analysis revealed the phospholipid compositional changes in muscle by chronic exercise and high-fat diet.
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DOI：
10.1038/srep03267
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发表时间：
2013-11-20
影响因子：
4.6
通讯作者：
Fujii, Nobuharu L.
中科院分区：
文献类型：
--
作者：
Goto-Inoue, Naoko;Yamada, Kenichiro;Inagaki, Akiko;Furuichi, Yasuro;Ogino, Shinya;Manabe, Yasuko;Setou, Mitsutoshi;Fujii, Nobuharu L.
虽然很明显，脂质是胰岛素抵抗的原因，但对涉及哪些类型的脂质知之甚少。在这项研究中，我们验证了在骨骼肌的慢性运动训练模型和高脂诱导肥胖模型的特征脂质种类。三种不同的脂质组学分析显示磷脂质的变化。结果表明，含亚油酸的磷脂酰胆碱和鞘磷脂以及含二十二碳六烯酸的磷脂酰胆碱被表征为慢性运动训练诱导的脂质。相反，含有花生四烯酸的磷脂酰胆碱、磷脂酰乙醇胺和磷脂酰肌醇被表征为高脂饮食诱导的脂质。此外，含有长链脂肪酸的次要鞘磷脂被鉴定为高脂饮食特异性脂质。这是第一份报告，揭示了在长期运动和高脂饮食诱导的胰岛素抵抗模型中磷脂分子种类的组成变化。由于它们对细胞膜的细胞渗透性和受体稳定性的影响，这些分子可能有助于胰岛素敏感性和几种代谢紊乱的潜在机制。
Although it is clear that lipids are responsible for insulin resistance, it is poorly understood what types of lipids are involved. In this study, we verified the characteristic lipid species in skeletal muscle of a chronic exercise training model and a high-fat induced-obesity model. Three different lipidomics analyses revealed phospholipid qualitative changes. As a result, linoleic acid-containing phosphatidylcholine and sphingomyelin and docosahexanoic acid-containing phosphatidylcholine were characterized as chronic exercise training-induced lipids. On the contrary, arachidonic acid-containing phosphatidylcholines, phosphatidylethanolamines, and phosphatidylinositol were characterized as high-fat diet-induced lipids. In addition, minor sphingomyelin, which has long-chain fatty acids, was identified as a high-fat diet-specific lipid. This is the first report to reveal compositional changes in phospholipid molecular species in chronic exercise and high-fat-diet-induced insulin-resistant models. Due to their influence on cell permeability and receptor stability at the cell membrane, these molecules may contribute to the mechanisms underlying insulin sensitivity and several metabolic disorders.
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影响因子：
6.9
作者：
Sene-Fiorese, Marcela;Duarte, Fernanda O.;Damaso, Ana R.
通讯作者：
Damaso, Ana R.
影响因子：
3.7
作者：
Ishikawa S;Tateya I;Hayasaka T;Masaki N;Takizawa Y;Ohno S;Kojima T;Kitani Y;Kitamura M;Hirano S;Setou M;Ito J
通讯作者：
Ito J
DOI：
10.1007/s004210050532
发表时间：
1999-04-01
期刊：
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY
影响因子：
--
作者：
Górski, J;Zendzian-Piotrowska, M;Glatz, JFC
通讯作者：
Glatz, JFC
影响因子：
1.6
作者：
Goto-Inoue, Naoko;Setou, Mitsutoshi;Zaima, Nobuhiro
通讯作者：
Zaima, Nobuhiro
影响因子：
7.7
作者：
Pan, DA;Lillioja, S;Storlien, LH
通讯作者：
Storlien, LH