Sex differences associated with adverse drug reactions resulting in hospital admissions.
Sex differences associated with adverse drug reactions resulting in hospital admissions.
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与不良药物反应有关的性别差异导致住院。
DOI：
10.1186/s13293-021-00377-0
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发表时间：
2021-05-03
影响因子：
7.9
通讯作者：
Visser LE
中科院分区：
文献类型：
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作者：
Hendriksen LC;van der Linden PD;Lagro-Janssen ALM;van den Bemt PMLA;Siiskonen SJ;Teichert M;Kuiper JG;Herings RMC;Stricker BH;Visser LE
药物不良事件，包括药物不良反应(ADRs)，约占计划外住院的5%：这是一个主要的健康问题。女性患ADR的可能性是女性的1.5-1.7倍。主要目的是确定导致住院的不良反应的类型和数量的性别差异。2005至2017年间与ADR相关的入院情况是从PHARMO数据库网络使用出院诊断确定的。≥患者年龄16岁，入院前3个月内服用可能导致不良反应的药物。计算年龄调整后的优势比(OR)，其中女性与男性的药物-ADR组合的CI为95%。共有18,469例与ADR相关的女性入院(占所有入院女性的0.35%)和14,678例涉及男性的入院(占所有入院男性的0.35%)。最显著的差异是由于抗凝剂和利尿剂导致的不良反应。女性患者发生持续性血尿(ORADJ 0.31；95%CI 0.21，0.45)、咯血(ORADJ 0.47，95%CI 0.30，0.74)和硬膜下出血(ORADJ 0.61；95%CI 0.42，0.88)的风险低于男性，而直肠出血的风险高于男性(ORADJ 1.48；95%CI 1.04，2.11)。此外，服用噻嗪类利尿剂导致低钾血症(ORADJ 3.03；95%可信区间1.58，5.79)和低钠血症(ORADJ 3.33，95%可信区间2.31，4.81)的女性入院风险高于男性。在特定的药物-ADR组合中，住院风险存在性别相关的差异。最显著的差异是由于抗凝剂和利尿剂。网上版载有补充材料，可在10.1186/s13293-021-00377-0查阅。
Adverse drug events, including adverse drug reactions (ADRs), are responsible for approximately 5% of unplanned hospital admissions: a major health concern. Women are 1.5–1.7 times more likely to develop ADRs. The main objective was to identify sex differences in the types and number of ADRs leading to hospital admission. ADR-related hospital admissions between 2005 and 2017 were identified from the PHARMO Database Network using hospital discharge diagnoses. Patients aged ≥ 16 years with a drug possibly responsible for the ADR and dispensed within 3 months before admission were included. Age-adjusted odds ratios (OR) with 95% CIs for drug-ADR combinations for women versus men were calculated. A total of 18,469 ADR-related hospital admissions involving women (0.35% of all women admitted) and 14,678 admissions involving men (0.35% of all men admitted) were included. Most substantial differences were seen in ADRs due to anticoagulants and diuretics. Anticoagulants showed a lower risk of admission with persistent haematuria (ORadj 0.31; 95%CI 0.21, 0.45) haemoptysis (ORadj 0.47, 95%CI 0.30,0.74) and subdural haemorrhage (ORadj 0.61; 95%CI 0.42,0.88) in women than in men and a higher risk of rectal bleeding in women (ORadj 1.48; 95%CI 1.04,2.11). Also, there was a higher risk of admission in women using thiazide diuretics causing hypokalaemia (ORadj 3.03; 95%CI 1.58, 5.79) and hyponatraemia (ORadj 3.33, 95%CI 2.31, 4.81) than in men. There are sex-related differences in the risk of hospital admission in specific drug-ADR combinations. The most substantial differences were due to anticoagulants and diuretics. The online version contains supplementary material available at 10.1186/s13293-021-00377-0.
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影响因子：
--
作者：
Myasoedova, Elena;Crowson, Cynthia S.;Kremers, Hilal Maradit;Therneau, Terry M.;Gabriel, Sherine E.
通讯作者：
Gabriel, Sherine E.
影响因子：
3.4
作者：
de Vries, Sieta T.;Denig, Petra;van Puijenbroek, Eugene P.
通讯作者：
van Puijenbroek, Eugene P.
影响因子：
8.2
作者：
Beery AK;Zucker I
通讯作者：
Zucker I
影响因子：
18.2
作者：
Granger, Bradi B.;Ekman, Inger;Swedberg, Karl
通讯作者：
Swedberg, Karl
影响因子：
4.2
作者：
Leendertse, Anne J.;Visser, Djurre;van den Bemt, Patricia M. L. A.
通讯作者：
van den Bemt, Patricia M. L. A.