The role of astrocyte-mediated plasticity in neural circuit development and function.
The role of astrocyte-mediated plasticity in neural circuit development and function.
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DOI：
10.1186/s13064-020-00151-9
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发表时间：
2021-01-07
影响因子：
3.6
通讯作者：
Ackerman SD
中科院分区：
文献类型：
--
作者：
Perez-Catalan NA;Doe CQ;Ackerman SD
神经元网络能够经历称为可塑性的快速结构和功能变化，这对于神经系统发育期间塑造回路功能至关重要。这些变化的范围从毫秒级的短期修改到神经结构的长期重新排列，这种重新排列可能持续生物体的一生。神经可塑性在发育过程中最为突出，但在记忆形成、行为和疾病中也起着关键作用。因此，它是必不可少的定义和特点的发病机制，持续时间和形式的可塑性。星形胶质细胞是人类神经系统中数量最多的神经胶质细胞类型，是突触的组成部分，也是神经胶质网络的组成部分，可以在全回路水平上协调神经活动。此外，它们在胚胎发育后期到达中枢神经系统与感觉诱发活动的发生相关，使它们成为回路可塑性研究的一个有趣目标。过去十年的技术进步已经发现星形胶质细胞是电路组装和功能的重要调节者。在这里，我们提供了一个简短的历史观点，我们了解星形胶质细胞在神经系统中，并审查的最新进展，星形胶质细胞在调节电路可塑性和功能在神经系统发育和稳态。
Neuronal networks are capable of undergoing rapid structural and functional changes called plasticity, which are essential for shaping circuit function during nervous system development. These changes range from short-term modifications on the order of milliseconds, to long-term rearrangement of neural architecture that could last for the lifetime of the organism. Neural plasticity is most prominent during development, yet also plays a critical role during memory formation, behavior, and disease. Therefore, it is essential to define and characterize the mechanisms underlying the onset, duration, and form of plasticity. Astrocytes, the most numerous glial cell type in the human nervous system, are integral elements of synapses and are components of a glial network that can coordinate neural activity at a circuit-wide level. Moreover, their arrival to the CNS during late embryogenesis correlates to the onset of sensory-evoked activity, making them an interesting target for circuit plasticity studies. Technological advancements in the last decade have uncovered astrocytes as prominent regulators of circuit assembly and function. Here, we provide a brief historical perspective on our understanding of astrocytes in the nervous system, and review the latest advances on the role of astroglia in regulating circuit plasticity and function during nervous system development and homeostasis.
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星形胶质细胞诱导的突触发生的分子机制。
影响因子：
5.7
作者：
Baldwin KT;Eroglu C
通讯作者：
Eroglu C
影响因子：
5.5
作者：
AXELSSON, J;THESLEFF, S
通讯作者：
THESLEFF, S
影响因子：
5.1
作者：
Buosi, Andrea Schmidt;Matias, Isadora;Alcantara Gomes, Flavia Carvalho
通讯作者：
Alcantara Gomes, Flavia Carvalho
DOI：
10.1016/j.cub.2020.10.012
发表时间：
2021-01-11
期刊：
Current biology : CB
影响因子：
--
作者：
Blum ID;Keleş MF;Baz ES;Han E;Park K;Luu S;Issa H;Brown M;Ho MCW;Tabuchi M;Liu S;Wu MN
通讯作者：
Wu MN
影响因子：
--
作者：
Berger, H
通讯作者：
Berger, H