Effect of divalproex on brain morphometry, chemistry, and function in youth at high-risk for bipolar disorder: a pilot study.
Effect of divalproex on brain morphometry, chemistry, and function in youth at high-risk for bipolar disorder: a pilot study.
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DOI：
10.1089/cap.2008.060
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发表时间：
2009-02
影响因子：
1.9
通讯作者：
Reiss A
中科院分区：
文献类型：
--
作者：
Chang K;Karchemskiy A;Kelley R;Howe M;Garrett A;Adleman N;Reiss A
双丙戊酸钠已被发现有效治疗青少年双相情感障碍（BD）和高风险，但很少有人知道情绪稳定剂对大脑本身的影响。我们试图研究双丙戊酸钠对BD高危儿童特定脑区的结构、化学和功能的影响。共有24名患有情绪失调但未完全BD的儿童，均为BD父母的后代，接受双丙戊酸钠单药治疗12周。在基线和12周后，对11名受试者和6名健康对照者进行磁共振成像（MRI、磁共振波谱[MRS]和功能性MRI [fMRI]）扫描。在12周内，杏仁核或皮质体积没有明显变化。此外，没有发现神经代谢物比率的变化，但我们发现前额叶脑激活的减少程度与抑郁症状严重程度的减少程度相关。双丙戊酸钠治疗12周后，BD高风险的双相后代未显示大体形态学、神经代谢物或功能变化。潜在原因包括样本量小、药物暴露时间短或双丙戊酸钠在该特定人群中缺乏显著的神经生物学影响。
Divalproex has been found efficacious in treating adolescents with and at high risk for bipolar disorder (BD), but little is known about the effects of mood stabilizers on the brain itself. We sought to examine the effects of divalproex on the structure, chemistry, and function of specific brain regions in children at high-risk for BD. A total of 24 children with mood dysregulation but not full BD, all offspring of a parent with BD, were treated with divalproex monotherapy for 12 weeks. A subset of 11 subjects and 6 healthy controls were scanned with magnetic resonance imaging (MRI, magnetic resonance spectroscopy [MRS], and functional MRI [fMRI]) at baseline and after 12 weeks. There were no significant changes in amygdalar or cortical volume found over 12 weeks. Furthermore, no changes in neurometabolite ratios were found. However, we found the degree of decrease in prefrontal brain activation to correlate with degree of decrease in depressive symptom severity. Bipolar offspring at high risk for BD did not show gross morphometric, neurometabolite, or functional changes after 12 weeks of treatment with divalproex. Potential reasons include small sample size, short exposure to medications, or lack of significant neurobiological impact of divalproex in this particular population.
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影响因子：
5.4
作者：
Gallelli, KA;Wagner, CM;Chang, KD
通讯作者：
Chang, KD
DOI：
10.1097/chi.0b013e318167656e
发表时间：
2008-05-01
影响因子：
13.3
作者：
Ladouceur, Cecile D.;Almeida, Jorge R. C.;Phillips, Mary L.
通讯作者：
Phillips, Mary L.
影响因子：
4.7
作者：
Laeng, P;Pitts, RL;Altar, CA
通讯作者：
Altar, CA
DOI：
10.1089/104454603322724931
发表时间：
2003-12-01
影响因子：
1.9
作者：
Cecil, KM;DelBello, MP;Strakowski, SM
通讯作者：
Strakowski, SM
影响因子：
5.4
作者：
Chang, Kiki D.;Wagner, Christopher;Reiss, Allan
通讯作者：
Reiss, Allan