The effect of cigarette smoking use and cessation on serum insulin-like growth factors.
The effect of cigarette smoking use and cessation on serum insulin-like growth factors.
复制标题
DOI：
10.1038/sj.bjc.6602150
复制
发表时间：
2004-10-18
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
在吸烟和非吸烟相关的癌症中，循环中胰岛素样生长因子(IGF)- 1及其主要结合蛋白IGFBP-3水平之间的风险关联模式有所不同。为了进一步研究这一观察结果，我们测量了232名男性和210名女性（55-64岁）的血清IGF-I、IGF-II和igf结合蛋白-3的浓度，以及与吸烟特征相关的肽水平。目前吸烟与男性平均IGFBP-3水平的显著降低有关，这是通过每天吸烟的数量（p趋势=0.007）和吸烟包年（p趋势=0.03）来评估的。平均igf - 1水平随着男性吸烟的增加而下降（p趋势=0.11）。在女性中，吸烟和IGF肽之间没有关联模式。对于男性戒烟者和从不吸烟者，igf - 1和IGFBP-3的平均浓度没有差异，这表明戒烟与肽浓度正常化有关。
The patterns of risk association between circulating levels of insulin-like growth factor (IGF)-I, and its main binding protein, IGFBP-3, differ between smoking and nonsmoking-related cancers. To investigate this observation further, we measured serum IGF-I, IGF-II and IGF-binding protein-3 concentrations in 232 men and 210 women (aged 55–64 years), and related peptide levels to smoking characteristics. Current smoking was associated with significant reductions in mean IGFBP-3 levels in men assessed by the number of cigarettes smoked daily (Ptrend=0.007) and pack-years smoked (Ptrend=0.03). Mean IGF-I levels decreased with increasing cigarette use in men (Ptrend=0.11). There were no patterns of association between smoking and IGF peptides in women. For male former vs never smokers, there were no differences in mean IGF-I and IGFBP-3 concentrations, suggesting that smoking cessation is associated with normalisation of peptide concentrations.
登录
查看更多内容
影响因子：
13
作者：
Clemmons, David R.
通讯作者：
Clemmons, David R.
影响因子：
8.4
作者：
Pollak, M
通讯作者：
Pollak, M
影响因子：
4
作者：
McCaig, C;Perks, CM;Holly, JMP
通讯作者：
Holly, JMP
影响因子：
5
作者：
GoodmanGruen, D;BarrettConnor, E
通讯作者：
BarrettConnor, E
影响因子：
2.3
作者：
Allen, NE;Appleby, PN;Key, TJ
通讯作者：
Key, TJ