Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population.
Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population.
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DOI：
10.1289/ehp.5742
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发表时间：
2003-02
影响因子：
10.4
通讯作者：
Whyatt RM
中科院分区：
文献类型：
--
作者：
Perera FP;Rauh V;Tsai WY;Kinney P;Camann D;Barr D;Bernert T;Garfinkel R;Tu YH;Diaz D;Dietrich J;Whyatt RM
在市中心，少数民族人口是不良出生结果的高危人群，也更有可能暴露于环境污染物，包括环境烟草烟雾（ETS）、多环芳烃（PAHs）和农药。在263名非吸烟的非洲裔美国妇女和多米尼加妇女的样本中，我们评估了产前暴露于怀孕期间通过个人空气采样监测的空气中多环芳烃，以及通过血浆可替宁估计的ETS和通过血浆毒死蜱（CPF）估计的有机磷农药（OP）对出生结果的影响。使用血浆CPF作为协变量，因为它在血浆中最常被检测到，并且与血浆中经常检测到的其他农药高度相关。在非裔美国人中，在调整了潜在的混杂因素后，产前高暴露于多环芳烃与低出生体重（p = 0.003）和头围（p = 0.01）相关。CPF与总体出生体重和出生长度的减少（分别为p = 0.01和p = 0.003）以及非洲裔美国人出生体重的减少（p = 0.04）和多米尼加人出生长度的减少（p < 0.001）相关，因此被纳入PAH模型的协变量。在控制CPF后，多环芳烃与出生结局之间的关系基本不变。在这项分析中，多环芳烃和CPF似乎是出生结果的重要独立决定因素。将对农药进行进一步分析。对未能在西班牙亚样本中发现多环芳烃显著影响的可能解释进行了讨论。这项研究提供了证据，目前在纽约市遇到的环境污染物水平会对胎儿发育产生不利影响。
Inner-city, minority populations are high-risk groups for adverse birth outcomes and also are more likely to be exposed to environmental contaminants, including environmental tobacco smoke (ETS), polycyclic aromatic hydrocarbons (PAHs), and pesticides. In a sample of 263 nonsmoking African-American and Dominican women, we evaluated the effects on birth outcomes of prenatal exposure to airborne PAHs monitored during pregnancy by personal air sampling, along with ETS estimated by plasma cotinine, and an organophosphate pesticide (OP) estimated by plasma chlorpyrifos (CPF). Plasma CPF was used as a covariate because it was the most often detected in plasma and was highly correlated with other pesticides frequently detected in plasma. Among African Americans, high prenatal exposure to PAHs was associated with lower birth weight (p = 0.003) and smaller head circumference (p = 0.01) after adjusting for potential confounders. CPF was associated with decreased birth weight and birth length overall (p = 0.01 and p = 0.003, respectively) and with lower birth weight among African Americans (p = 0.04) and reduced birth length in Dominicans (p < 0.001), and was therefore included as a covariate in the model with PAH. After controlling for CPF, relationships between PAHs and birth outcomes were essentially unchanged. In this analysis, PAHs and CPF appear to be significant independent determinants of birth outcomes. Further analyses of pesticides will be carried out. Possible explanations of the failure to find a significant effect of PAHs in the Hispanic subsample are discussed. This study provides evidence that environmental pollutants at levels currently encountered in New York City adversely affect fetal development.
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影响因子：
158.5
作者：
JANERICH, DT;THOMPSON, WD;MCKNEALLY, MF
通讯作者：
MCKNEALLY, MF
影响因子：
10.4
作者：
LEIKAUF, GD;KLINE, S;BUNCHER, CR
通讯作者：
BUNCHER, CR
影响因子：
5
作者：
CHEN, LH;PETITTI, DB
通讯作者：
PETITTI, DB
DOI：
10.1016/s0378-4347(01)00444-3
发表时间：
2002-10-05
影响因子：
3
作者：
Barr, DB;Barr, JR;Needham, LL
通讯作者：
Needham, LL
影响因子：
10.4
作者：
Faustman, EM;Silbernagel, SM;Ponce, RA
通讯作者：
Ponce, RA