An Impact of Psychological Stress on the Interplay between Salivary Oxidative Stress and the Classic Psychological Stress-Related Parameters.
An Impact of Psychological Stress on the Interplay between Salivary Oxidative Stress and the Classic Psychological Stress-Related Parameters.
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DOI：
10.1155/2021/6635310
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发表时间：
2021
影响因子：
--
通讯作者：
Radulović NS
中科院分区：
文献类型：
--
作者：
Stojanović NM;Randjelović PJ;Pavlović D;Stojiljković NI;Jovanović I;Sokolović D;Radulović NS
氧化和心理（精神）压力都可能是几种急性和慢性健康障碍的罪魁祸首，需要进行适当的模拟测试。本文中，在受控的实验室环境中，使用PEBL（心理学实验构建语言）测试组合来引起应激相关的生物反应，然后跟踪唾液参数的变化。本研究的目的是确定心理应激对选定的流涎参数的影响，并评估确定的氧化和应激参数之间的相关性。该研究在36名健康年轻受试者中进行，主要是女性（n = 24）。在完成一组四次PEBL测试之前和之后，收集受试者的唾液样本。应激诱发的总抗氧化能力和亚硝酸盐/硝酸盐水平的变化，作为氧化应激参数，皮质醇和免疫球蛋白A（伊加），作为心理应激的参数，建立和相互关联，通过比较评估参数的值前和后PEBL测试。结果表明，总唾液抗氧化能力没有变化（p > 0.05）;然而，PEBL试验后亚硝酸盐/硝酸盐水平显著增加（p = 0.007）。另一方面，与试验前的值相比，试验后测定的皮质醇水平在统计学上显著增加（p = 0.025），而伊加水平在统计学上显著降低（p < 0.001）。研究参数变化之间唯一具有统计学意义的相关性是皮质醇和伊加水平之间的相关性（斯皮尔曼R = -0.4）。这些结果表明，PEBL测试引起的短期压力引起的唾液心理应激相关参数的变化（皮质醇和亚硝酸盐/硝酸盐水平的增加，伊加的减少），但不是在总的抗氧化能力。他们还表明，构建的PEBL四次测试组合可能代表了足够的实验室应激诱导范式。
Both oxidative and psychological (mental) stress are the likely culprits for several acute and chronic health disturbances, and adequate tests mimicking that are needed. Herein, in controlled laboratory surroundings, a PEBL (Psychology Experiment Building Language) test battery was used to evoke stress-related biological responses followed by tracking changes in saliva parameters. The study objectives were to determine the impact of psychological stress on selected salivatory parameters and to assess the correlation between the determined oxidative and stress parameters. The study was conducted on 36 healthy young subjects, mainly females (n = 24). Before and following the completion of a battery of four PEBL tests, subjects' saliva samples were collected. Stress-evoking changes in total antioxidant capacity and nitrite/nitrate levels, as oxidative stress parameters, and cortisol and immunoglobulin A (IgA), as parameters of psychological stress, were established and mutually correlated by comparing the values of the evaluated parameters pre- and post-PEBL test. The results showed that there is no change in the total salivary antioxidant capacity (p > 0.05); however, there was a significant increase in nitrites/nitrates levels after the PEBL test (p = 0.007). On the other hand, the determined cortisol levels after the test battery were found to be statistically significantly increased (p = 0.025) when compared to the values obtained before the test, while the levels of IgA were found to be statistically significantly decreased (p < 0.001). The only statistically significant correlation between the changes in the studied parameters was found to be the one between cortisol and IgA levels (Spearman's Rö = -0.4). These results suggest that the short-term stress induced by the PEBL test does evoke changes in the salivary mental stress-related parameters (an increase in cortisol and nitrite/nitrate levels, and a decrease in IgA), but not in the total antioxidant capacity. They also indicate that the constructed PEBL four-test battery might represent an adequate laboratory stress-inducing paradigm.
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