Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target.
Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target.
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DOI：
10.1038/s41467-023-40029-y
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发表时间：
2023-07-19
影响因子：
16.6
通讯作者：
Andres, Marta
中科院分区：
文献类型：
--
作者：
Georgiades, Marcos;Alampounti, Alexandros;Somers, Jason;Su, Matthew P. P.;Ellis, David A.;Bagi, Judit;Terrazas-Duque, Daniela;Tytheridge, Scott;Ntabaliba, Watson;Moore, Sarah;Albert, Joerg T.;Andres, Marta
疟疾蚊子在黄昏时短暂形成的大群中通过声音探测它们的交配伙伴。事实上，雄性疟疾蚊子在蜂群时间期间优选地对雌性飞行音调作出反应。这种现象意味着蚊子听觉的复杂的上下文和时间依赖性调制，其机制在很大程度上是未知的。使用转录组学，我们确定了一个复杂的网络候选神经调节蚊子的听觉冈比亚按蚊。其中，章鱼胺脱颖而出，作为一个听觉调制器在群集时间。对章鱼胺听觉功能的深入分析表明，它在多个层面上影响蚊子的耳朵：它调节鞭毛声音接收器的调谐和刚度，并控制触角纤丝的勃起。我们发现，两个α-和β-肾上腺素样章鱼胺受体驱动章鱼胺的听觉作用，并证明章鱼胺能听觉控制系统可以被杀虫剂靶向。我们的研究结果强调章鱼胺是蚊子听觉和交配伴侣检测的关键，也是蚊子控制的潜在新靶点。作为求偶仪式的一部分，疟疾蚊子用它们的耳朵来探测蜂群中交配伙伴的飞行音调。在这里，作者描述了章鱼胺作为疟疾蚊子听觉可塑性调节剂的听觉作用，并确定了参与这一过程的主要受体。
Malaria mosquitoes acoustically detect their mating partners within large swarms that form transiently at dusk. Indeed, male malaria mosquitoes preferably respond to female flight tones during swarm time. This phenomenon implies a sophisticated context- and time-dependent modulation of mosquito audition, the mechanisms of which are largely unknown. Using transcriptomics, we identify a complex network of candidate neuromodulators regulating mosquito hearing in the species Anopheles gambiae. Among them, octopamine stands out as an auditory modulator during swarm time. In-depth analysis of octopamine auditory function shows that it affects the mosquito ear on multiple levels: it modulates the tuning and stiffness of the flagellar sound receiver and controls the erection of antennal fibrillae. We show that two α- and β-adrenergic-like octopamine receptors drive octopamine’s auditory roles and demonstrate that the octopaminergic auditory control system can be targeted by insecticides. Our findings highlight octopamine as key for mosquito hearing and mating partner detection and as a potential novel target for mosquito control. Malaria mosquitoes use their ears to detect the flight tones of mating partners in the swarm as part of the courtship ritual. Here, the authors describe the auditory role of octopamine as a modulator of auditory plasticity in malaria mosquitoes and identify the main receptors involved in this process.
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影响因子：
1.2
作者：
Albert, Joerg T.;Nadrowksi, Bjoern;Goepfert, Martin C.
通讯作者：
Goepfert, Martin C.
影响因子：
6.7
作者：
Childs LM;Cai FY;Kakani EG;Mitchell SN;Paton D;Gabrieli P;Buckee CO;Catteruccia F
通讯作者：
Catteruccia F
影响因子：
15.8
作者：
malERA Refresh Consultative Panel on Insecticide and Drug Resistance
通讯作者：
malERA Refresh Consultative Panel on Insecticide and Drug Resistance
影响因子：
2.6
作者：
Du, W;Awolola, TS;Zheng, L
通讯作者：
Zheng, L
DOI：
10.1126/science.1166541
发表时间：
2009-02-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cator LJ;Arthur BJ;Harrington LC;Hoy RR
通讯作者：
Hoy RR