malERA: An updated research agenda for insecticide and drug resistance in malaria elimination and eradication.
malERA: An updated research agenda for insecticide and drug resistance in malaria elimination and eradication.
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DOI：
10.1371/journal.pmed.1002450
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发表时间：
2017-11
期刊：
影响因子：
15.8
通讯作者：
malERA Refresh Consultative Panel on Insecticide and Drug Resistance
中科院分区：
文献类型：
--
作者：
malERA Refresh Consultative Panel on Insecticide and Drug Resistance
对恶性疟原虫疟疾一线治疗药物和用于控制疟蚊媒介的杀虫剂的耐药性正威胁着消除疟疾的努力。对药物和杀虫剂的次优反应既在地理上蔓延，又独立出现，而且愈演愈烈。虽然耐药性不可避免，但可通过耐药性管理措施减轻其影响，例如将寄生虫或病媒暴露于一种以上的选择性制剂。耐药性是导致20世纪全球消灭疟疾规划失败的原因之一，但全球对这一问题的反应仍然缓慢和不协调——太频繁、太少、太迟。消灭疟疾研究议程（malERA）更新进程召集了一个关于杀虫剂和抗疟疾药物耐药性的小组。本文概述了过去5年该领域的发展，突出了知识上的差距，并提出了一个侧重于管理耐药性的研究议程。需要更深入地了解所涉及的复杂生物学过程以及如何选择耐药性，并提供其公共卫生影响的证据。抗性管理将需要在决策中改进昆虫学和寄生虫学数据的使用，并通过仔细的实施、组合和评估来优化新产品和现有产品的使用寿命。从基础科学和开发新工具到规划和政策干预，都需要一种积极主动的合作方法，以确保药物和杀虫剂的储备足以应对疟疾控制和消除的挑战。Janet Hemingway和他的同事检查了消除和根除疟疾中杀虫剂和药物耐药性的研究进展，并提出了一项研究议程。
Resistance to first-line treatments for Plasmodium falciparum malaria and the insecticides used for Anopheles vector control are threatening malaria elimination efforts. Suboptimal responses to drugs and insecticides are both spreading geographically and emerging independently and are being seen at increasing intensities. Whilst resistance is unavoidable, its effects can be mitigated through resistance management practices, such as exposing the parasite or vector to more than one selective agent. Resistance contributed to the failure of the 20th century Global Malaria Eradication Programme, and yet the global response to this issue continues to be slow and poorly coordinated—too often, too little, too late. The Malaria Eradication Research Agenda (malERA) Refresh process convened a panel on resistance of both insecticides and antimalarial drugs. This paper outlines developments in the field over the past 5 years, highlights gaps in knowledge, and proposes a research agenda focused on managing resistance. A deeper understanding of the complex biological processes involved and how resistance is selected is needed, together with evidence of its public health impact. Resistance management will require improved use of entomological and parasitological data in decision making, and optimisation of the useful life of new and existing products through careful implementation, combination, and evaluation. A proactive, collaborative approach is needed from basic science and the development of new tools to programme and policy interventions that will ensure that the armamentarium of drugs and insecticides is sufficient to deal with the challenges of malaria control and its elimination. Janet Hemingway and colleagues examine progress in research on insecticide and drug resistance in malaria elimination and eradication and propose a research agenda.
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DOI：
10.1016/s0140-6736(15)00417-1
发表时间：
2016-04-23
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hemingway J;Ranson H;Magill A;Kolaczinski J;Fornadel C;Gimnig J;Coetzee M;Simard F;Roch DK;Hinzoumbe CK;Pickett J;Schellenberg D;Gething P;Hoppé M;Hamon N
通讯作者：
Hamon N
柬埔寨恶性疟原虫疟疾中的双氢青蒿素-哌喹抗药性：一项多地点前瞻性队列研究。
DOI：
10.1016/s1473-3099(15)00487-9
发表时间：
2016-03
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Amaratunga C;Lim P;Suon S;Sreng S;Mao S;Sopha C;Sam B;Dek D;Try V;Amato R;Blessborn D;Song L;Tullo GS;Fay MP;Anderson JM;Tarning J;Fairhurst RM
通讯作者：
Fairhurst RM
影响因子：
3
作者：
Glunt KD;Paaijmans KP;Read AF;Thomas MB
通讯作者：
Thomas MB
影响因子：
15.8
作者：
Alonso PL;Brown G;Arevalo-Herrera M;Binka F;Chitnis C;Collins F;Doumbo OK;Greenwood B;Hall BF;Levine MM;Mendis K;Newman RD;Plowe CV;Rodríguez MH;Sinden R;Slutsker L;Tanner M
通讯作者：
Tanner M
影响因子：
11.8
作者：
Chanda, Emmanuel;Thomsen, Edward K.;Coleman, Michael
通讯作者：
Coleman, Michael