Occurrence of multidrug-resistant and ESBL-producing atypical enteropathogenic Escherichia coli in China.
Occurrence of multidrug-resistant and ESBL-producing atypical enteropathogenic Escherichia coli in China.
复制标题
中国多重耐药及产ESBL非典型致病性大肠杆菌的出现
DOI：
10.1186/s13099-018-0234-0
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发表时间：
2018
期刊：
影响因子：
4.2
通讯作者：
Xiong Y
中科院分区：
文献类型：
--
作者：
Xu Y;Sun H;Bai X;Fu S;Fan R;Xiong Y
背景：非典型肠致病菌大肠杆菌（aEPEC）被认为是一种全球性的新兴肠致病菌。aEPECs对一系列抗生素表现出不同程度的耐药性，这种耐药性正在惊人地增加。本研究调查了从腹泻患者、健康携带者、动物和生肉中分离出的aEPEC菌株的耐药性。结果：267株aEPEC菌株中，对四环素耐药146株（54.7%），其次是氨苄西林（49.4%）、链霉素（46.1%）和哌西林（41.2%）。128株（47.9%）检测到耐多药（MDR），其中40株耐药≥10种抗菌药物。共有47株（17.6%）aEPEC分离株被鉴定为广谱β-内酰胺酶（ESBL）产生菌。blactx - m -14和blactx - m -15基因在产生esbl的分离株中占主导地位。结论：该调查描述了在中国发生的多药耐药和产生esbl的aEPEC分离株。结果提示，有必要对耐多药aEPEC的出现和传播情况进行持续监测。
Background:Atypical enteropathogenicEscherichia coli(aEPEC) is regarded as a globally emerging enteropathogen. aEPECs exhibit various level of resistance to a range of antibiotics, which is increasing alarmingly. The present study investigated the antimicrobial resistance of aEPEC isolates recovered from diarrheal patients, healthy carriers, animals, and raw meats.Results:Among 267 aEPEC isolates, 146 (54.7%) were resistant to tetracycline, followed by ampicillin (49.4%), streptomycin (46.1%), and piperacillin (41.2%). Multidrug resistance (MDR) was detected in 128 (47.9%) isolates, and 40 MDR isolates were resistant to ≥ 10 antimicrobial agents. A total of 47 (17.6%) aEPEC isolates were identified as extended-spectrum β-lactamase (ESBL)-producers. TheblaCTX-M-14andblaCTX-M-15genes were predominant among ESBL-producing isolates.Conclusions:This investigation depicted the occurrence of multidrug-resistant and ESBL-producing aEPEC isolates in China. The results suggested that it is necessary to continuously monitor the emergence and spread of MDR aEPEC.
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影响因子：
2.6
作者：
Lee WC;Yeh KS
通讯作者：
Yeh KS
影响因子：
2.2
作者：
Bakhshi, Bita;Fallahzad, Soheil;Pourshafie, Mohammad R.
通讯作者：
Pourshafie, Mohammad R.
影响因子：
168.9
作者：
Liu, Li;Johnson, Hope L.;Black, Robert E.
通讯作者：
Black, Robert E.
DOI：
10.1590/s0120-41572014000300013
发表时间：
2014-09-01
期刊：
Biomédica
影响因子：
--
作者：
Maldonado, Natalia Andrea;Múnera, María Isabel;Robledo, Jaime
通讯作者：
Robledo, Jaime
影响因子：
3.7
作者：
Lanata CF;Fischer-Walker CL;Olascoaga AC;Torres CX;Aryee MJ;Black RE;Child Health Epidemiology Reference Group of the World Health Organization and UNICEF
通讯作者：
Child Health Epidemiology Reference Group of the World Health Organization and UNICEF