Presentation of phagocytosed antigens by MHC class I and II.
Presentation of phagocytosed antigens by MHC class I and II.
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DOI：
10.1111/tra.12026
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发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
Marks MS
中科院分区：
文献类型：
--
作者：
Mantegazza AR;Magalhaes JG;Amigorena S;Marks MS
吞噬作用为先天免疫细胞提供了一种机制，以吸收和破坏病原菌，凋亡细胞和其他大颗粒。然而，在某些情况下，来自这些颗粒的肽抗原被保存用于与主要组织相容性复合体（MHC）I类或II类分子联合呈递，以刺激抗原特异性T细胞。来自吞噬体的抗原的加工和呈递相对于通过其他方式内化的抗原呈现出许多不同的挑战;虽然细菌抗原是最早发现的呈递给T细胞的抗原之一，对来自被吞噬抗原的肽与MHC分子组装以及这些复合物随后在质膜上表达的细胞机制的分析已经落后于那些常规的可溶性模型，抗原在这篇综述中，我们涵盖了我们对这些过程的理解的最新进展，包括MHC I类分子对吞噬抗原的独特交叉呈递，以及它们在吞噬细胞中的信号传导方式的控制。
Phagocytosis provides innate immune cells with a mechanism to take up and destroy pathogenic bacteria, apoptotic cells and other large particles. In some cases, however, peptide antigens from these particles are preserved for presentation in association with major histocompatibility complex (MHC) class I or class II molecules in order to stimulate antigen-specific T cells. Processing and presentation of antigens from phagosomes presents a number of distinct challenges relative to antigens internalized by other means; While bacterial antigens were among the first discovered to be presented to T cells, analyses of the cellular mechanisms by which peptides from phagocytosed antigens assemble with MHC molecules and by which these complexes are then expressed at the plasma membrane have lagged behind those of conventional model soluble antigens. In this review, we cover recent advances in our understanding of these processes, including the unique cross-presentation of phagocytosed antigens by MHC class I molecules, and in their control by signaling modalities in phagocytic cells.
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