HIV incidence and predictors associated with retention in a cohort of men who have sex with men in Yangzhou, Jiangsu Province, China.
HIV incidence and predictors associated with retention in a cohort of men who have sex with men in Yangzhou, Jiangsu Province, China.
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DOI：
10.1371/journal.pone.0052731
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Chen F
中科院分区：
文献类型：
--
作者：
Peng Z;Yang H;Norris J;Chen X;Huan X;Yu R;Wang N;Shen H;Chen F
该研究旨在调查中国江苏省扬州市男男性行为者（MSM）中HIV-1的发病率和相关因素，以及与保留相关的预测因素。进行了一项精心设计的为期12个月的前瞻性队列研究。自2008年5月起，共招募血清阴性男男性行为者278例，随访12个月。参与者在基线、6个月和12个月的随访中进行HIV-1检测。通过问卷访谈收集信息。以人口学和行为变量为函数，分析艾滋病病毒的保留率和发病率。采用泊松回归模型、单因素分析、多因素分析和危险因素分析，通过估计相对危险度（RR）和各自的95%置信区间（CI）来确定危险因素。278名参与者中，分别有71名（25.5%）和45名（16.2%）在6个月和12个月的随访中被保留。HIV-1的发病率分别为5.65和6.67 / 100人年（PY）。在12个月的随访中，使用避孕套和使用润滑剂的人与HIV血清转化呈负相关。与12个月保留率相关的预测因子包括：扬州户籍（RR = 0.471, 95%CI: 0.275 ~ 0.807, P = 0.006）、是否接受安全套（RR = 0.065, 95%CI: 0.007 ~ 0.572, P = 0.014）和是否接受过vct （RR = 0.093, 95%CI: 0.010 ~ 0.818, P = 0.032）。扬州市男男性行为者HIV-1感染率较高，急需采取有效的干预措施。更多的注意力应该集中在保持较高的留存率上。
The study was to investigate the incidence of HIV-1 and related factors, as well as predictors associated with retention in a cohort study among men who have sex with men (MSM) in Yangzhou, Jiangsu Province, China. A carefully designed 12-month prospective cohort study was conducted. A total of 278 sero-negative MSM were recruited and followed up for 12 months starting from May, 2008. Participants were tested for HIV-1 at baseline, 6-month, and 12-month follow-up visits. Questionnaire interviews were conducted to collect information. The retention rate and HIV incidence were analyzed as functions of demographic and behavioral variables. Risk factors were identified by estimating the relative risks (RR) and respective 95% confidence intervals (CI) using a Poisson regression model, univariate and multivariate analyses and risk factors analyses. 71 (25.5%) and 45 (16.2%) of the 278 participants were retained at the 6-month and 12-month follow-up visits respectively. The incidence rates of HIV-1 were 5.65 and 6.67 per 100 person years (PY) respectively. Both having received condoms and having received lubricant were negatively associated with HIV sero-conversion at the 12 months’ follow-up. Predictors associated with 12-month retention rate include Yangzhou residency (RR = 0.471, 95%CI: 0.275∼0.807, P = 0.006), having received condoms (RR = 0.065, 95%CI: 0.007∼0.572, P = 0.014), and having received VCTs (RR = 0.093, 95%CI: 0.010∼0.818, P = 0.032). The incidence of HIV-1 among MSM in Yangzhou is relatively high and effective interventions are needed urgently. More attention should be focused on maintaining a higher retention rate.
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中国江苏省男男性行为者中 HIV 和梅毒患病率迅速上升以及 HIV-1 亚型特征
影响因子：
3.1
作者：
Guo, Hongxiong;Wei, Ji-Fu;Zhang, Chiyu
通讯作者：
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影响因子：
6.1
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Shao Yi-Ming
DOI：
10.1097/qai.0b013e3181b56404
发表时间：
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影响因子：
3.6
作者：
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通讯作者：
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影响因子：
3.6
作者：
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通讯作者：
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影响因子：
4.4
作者：
Ruan, Yuhua;Luo, Fengji;Jia, Yujiang;Li, Xinxu;Li, Qingchun;Liang, Hongyuan;Zhang, Xiaoxi;Li, Dongliang;Shi, Wei;Freeman, Jennifer M.;Vermund, Sten H.;Shao, Yiming
通讯作者：
Shao, Yiming