Organically derived exosomes as carriers of anticancer drugs and imaging agents for cancer treatment.
Organically derived exosomes as carriers of anticancer drugs and imaging agents for cancer treatment.
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DOI：
10.1016/j.semcancer.2022.02.020
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发表时间：
2022-11
影响因子：
14.5
通讯作者：
Ramesh, Rajagopal
中科院分区：
文献类型：
--
作者：
Srivastava, Akhil;Rathore, Shipra;Munshi, Anupama;Ramesh, Rajagopal
细胞外小泡(EVS)是细胞产生的不同类型的小泡的总称，其中外切体是最大的一类。胞外体通过携带来自供体或亲本细胞的几种生物制剂并将它们输送到受体细胞来执行细胞间通信。它们独特的载货能力最近被探索用于抗癌药物和显像剂的运输工具。由于是自然产生的，与目前临床上用于治疗癌症和其他疾病的合成脂基纳米粒相比，外切体具有许多优势。随着外切体在人类疾病中作用的发现，许多临床前和临床研究探索了它们在癌症诊断和治疗中作为顺应性药物载体和治疗药物的用途。然而，与外切体相关的某些限制，最重要的是大规模生产高度生物相容的外切体的生物来源的选择。这篇综述文章探索了各种来源，从那里可以分离出治疗上可行的外切体，用作癌症治疗的药物载体。在后续章节中还讨论了外切体的分离方法以及将它们装载到癌症治疗药物和显像剂中的过程。最后，文章对外切体在癌症诊断和治疗中的应用进行了展望。
Extracellular vesicles (EVs), is the umbrella term used for different types of vesicles produced by the cells, among which exosomes form the largest group. Exosomes perform intercellular communication by carrying several biologics from donor or parental cells and delivering them to recipient cells. Their unique cargo-carrying capacity has recently been explored for use as delivery vehicles of anticancer drugs and imaging agents. Being naturally produced, exosomes have many advantages over synthetic lipid-based nanoparticles currently being used clinically to treat cancer and other diseases. The finding of the role of exosomes in human diseases has led to numerous preclinical and clinical studies exploring their use as an amenable drug delivery vehicle and a theranostic in cancer diagnosis and treatment. However, there are certain limitations associated with exosomes, with the most important being the selection of the biological source for producing highly biocompatible exosomes on a large scale. This review article explores the various sources from which therapeutically viable exosomes can be isolated for use as drug carriers for cancer treatment. The methods of exosome isolation and the process of loading them with cancer therapeutics and imaging agents are also discussed in the follow-up sections. Finally, the article concludes with future directions for exosome-based applications in cancer diagnosis and treatment.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
影响因子：
7.3
作者：
Andreu Z;Yáñez-Mó M
通讯作者：
Yáñez-Mó M
DOI：
10.1038/nrmicro3480
发表时间：
2015-10
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
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通讯作者：
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影响因子：
2.4
作者：
Bongiovanni L;Andriessen A;Wauben MHM;Nolte-'t Hoen ENM;de Bruin A
通讯作者：
de Bruin A
影响因子：
9.7
作者：
Aqil, Farrukh;Munagala, Radha;Gupta, Ramesh C.
通讯作者：
Gupta, Ramesh C.