Exercise after diagnosis and metabolic syndrome among breast cancer survivors: a report from the Shanghai Breast Cancer Survival Study.
Exercise after diagnosis and metabolic syndrome among breast cancer survivors: a report from the Shanghai Breast Cancer Survival Study.
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DOI：
10.1007/s10552-013-0252-7
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发表时间：
2013-09
影响因子：
2.3
通讯作者：
Lu, Wei
中科院分区：
文献类型：
--
作者：
Bao, Ping-Ping;Zheng, Ying;Nechuta, Sarah;Gu, Kai;Cai, Hui;Peng, Peng;Shu, Xiao-Ou;Lu, Wei
代谢综合征（MetS）是心血管疾病和死亡的一个既定的危险因素。关于乳腺癌幸存者中代谢综合征的患病率及其与运动的相关性的数据有限。本研究纳入了来自上海乳腺癌生存研究的1696名乳腺癌幸存者，该研究是一项基于人群的前瞻性队列研究，于2002年4月至2011年10月在中国上海进行。所有女性在诊断后约60个月在研究诊所进行体格检查。在诊断后约6、18、36和60个月评估运动。在研究入组时收集病史、肿瘤特征、癌症治疗、人体测量学和生活方式等信息。在诊断后60个月，运动和代谢综合征之间的关联进行了评估，多变量逻辑回归模型。60个月调查时，研究人群的平均年龄为56.68岁，自癌症诊断以来的平均随访时间为63.66个月。在诊断后约60个月时，使用NCEP-ATP III标准的MetS患病率为33.14%。在超重和肥胖乳腺癌幸存者（基线BMI≥25 kg/m2）中，患病率为55.18%。基线时，该人群中最常见的运动类型为步行（45.40%）。诊断后6至60个月的运动参与与MetS的患病率呈负相关，运动参与≥3.5小时/周（30分钟/天）的校正OR为0.69（95%CI：0. 05）。0.48-0.98）。此外，坚持锻炼可降低代谢综合征的患病率（校正OR 0.70（95%CI：0.50-1.00）。运动与代谢综合征之间的关系不受基线腰围、体重指数、合并症、基线绝经状态、TNM分期、癌症治疗或ER/PR状态的影响（P相互作用>0.05）。癌症诊断后定期和持续的运动，即使是低到中等强度的运动，也可以降低长期乳腺癌幸存者中MetS的患病率。
Metabolic syndrome (MetS) is an established risk factor for cardiovascular diseases and mortality. Limited data are available on the prevalence of MetS and its association with exercise among breast cancer survivors. The present study included 1696 breast cancer survivors from the Shanghai Breast Cancer Survival Study, a population-based prospective cohort study conducted between April 2002 and October 2011 in Shanghai, China. All women had a physical examination taken at study clinic approximately 60 months post-diagnosis. Exercise was assessed at approximately 6, 18, 36, and 60 months post-diagnosis. Information on medical history, tumor characteristics, cancer treatment, anthropometrics, and lifestyle were collected at study enrollment. Associations between exercise and MetS at 60 months post-diagnosis were evaluated with multivariable logistic regression models. The mean age of the study population was 56.68 at 60-month survey and the mean follow-up since cancer diagnosis was 63.66 months. The prevalence of MetS using NCEP-ATPIII criteria at approximately 60 months after diagnosis was 33.14%. Among overweight and obesity breast cancer survivors (BMI≥25 kg/m2 at baseline), the prevalence was 55.18%. The most common type of exercise in this population was walking (45.40%) at baseline. Exercise participation between 6 and 60 months post-diagnosis was inversely associated with the prevalence of MetS with the adjusted OR for exercise participation of ≥3.5 hours/week (30 minutes/day) being 0.69 (95% CI: 0. 0.48–0.98). In addition consistent exercise participation reduced the prevalence of MetS (adjusted OR 0.70 (95%CI: 0.50–1.00). Associations of exercise with MetS were not modified by baseline WC, BMI, comorbidity, baseline menopausal status, TNM stage, cancer treatment, or ER/PR status (P interactions >0.05). Regular and persistent exercise after cancer diagnosis, even at low-to-moderate intensity level, decrease the prevalence of MetS among long-term breast cancer survivors.
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影响因子：
45.3
作者：
Goodwin, PJ;Ennis, M;Hood, N
通讯作者：
Hood, N
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.
影响因子：
4.5
作者：
Nguyen, Trang H. H. D.;Tang, Hong K.;Dibley, Michael J.
通讯作者：
Dibley, Michael J.
影响因子：
6.4
作者：
Berrino, F;Pasanisi, P;Secreto, G
通讯作者：
Secreto, G
影响因子：
2.4
作者：
McTiernan, A
通讯作者：
McTiernan, A