A wearable multi-channel fNIRS system for brain imaging in freely moving subjects.
A wearable multi-channel fNIRS system for brain imaging in freely moving subjects.
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DOI：
10.1016/j.neuroimage.2013.06.062
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发表时间：
2014-01-15
期刊：
影响因子：
5.7
通讯作者：
Schmitz, Christoph H.
中科院分区：
文献类型：
--
作者：
Piper, Sophie K.;Krueger, Arne;Koch, Stefan P.;Mehnert, Jan;Habermehl, Christina;Steinbrink, Jens;Obrig, Hellmuth;Schmitz, Christoph H.
功能近红外光谱（fNIRS）是一种多功能的神经成像工具，在神经影像学界越来越被接受。虽然它的可移植性经常受到称赞，但大多数用于神经科学研究的近红外光谱装置仍然在实验室环境中使用。我们提出了一种可穿戴的多通道fNIRS成像系统，用于在不受约束的环境下进行功能性脑成像。该系统无需光纤束，使用8个双波长发光二极管和8个光电传感器，可以自由放置在受试者的头部，进行直接照明和检测。在运动执行范式中，对N = 8名被试在三种不同的运动条件下进行了测试：(i)在户外骑自行车时，（ii）在固定训练自行车上踩踏板时，（iii）在训练自行车上静坐时。在左手握紧之后，我们观察到在所有三种情况下对侧运动皮层的脱氧血红蛋白浓度显著下降。在不踩踏板的情况下，与任务相关的ΔHbO2显著增加。尽管与坐着不动相比，蹬车和驾驶自行车的总运动诱发了更多的运动假影，但我们发现，在室外或室内骑自行车和坐着不动时，HbR时间轨迹的形状或幅度没有显著差异。我们展示了在自然、不受约束的环境中剧烈运动时使用可穿戴多通道近红外光谱的一般可行性，并讨论了数据伪影的起源和影响。我们提供了考虑条件相关信号质量的定量指南，以便对不同水平的体育锻炼数据进行比较。据我们所知，这是人类在现实生活中户外活动中首次展示功能性近红外脑成像。
Functional near infrared spectroscopy (fNIRS) is a versatile neuroimaging tool with an increasing acceptance in the neuroimaging community. While often lauded for its portability, most of the fNIRS setups employed in neuroscientific research still impose usage in a laboratory environment. We present a wearable, multi-channel fNIRS imaging system for functional brain imaging in unrestrained settings. The system operates without optical fiber bundles, using eight dual wavelength light emitting diodes and eight electro-optical sensors, which can be placed freely on the subject's head for direct illumination and detection. Its performance is tested on N = 8 subjects in a motor execution paradigm performed under three different exercising conditions: (i) during outdoor bicycle riding, (ii) while pedaling on a stationary training bicycle, and (iii) sitting still on the training bicycle. Following left hand gripping, we observe a significant decrease in the deoxyhemoglobin concentration over the contralateral motor cortex in all three conditions. A significant task-related ΔHbO2 increase was seen for the non-pedaling condition. Although the gross movements involved in pedaling and steering a bike induced more motion artifacts than carrying out the same task while sitting still, we found no significant differences in the shape or amplitude of the HbR time courses for outdoor or indoor cycling and sitting still. We demonstrate the general feasibility of using wearable multi-channel NIRS during strenuous exercise in natural, unrestrained settings and discuss the origins and effects of data artifacts. We provide quantitative guidelines for taking condition-dependent signal quality into account to allow the comparison of data across various levels of physical exercise. To the best of our knowledge, this is the first demonstration of functional NIRS brain imaging during an outdoor activity in a real life situation in humans.
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