Damage to the fronto-polar cortex is associated with impaired multitasking.
Damage to the fronto-polar cortex is associated with impaired multitasking.
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DOI：
10.1371/journal.pone.0003227
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发表时间：
2008-09-16
期刊：
影响因子：
3.7
通讯作者：
Grafman J
中科院分区：
文献类型：
--
作者：
Dreher JC;Koechlin E;Tierney M;Grafman J
了解大脑功能组织的一个主要问题是描绘前额叶皮层的功能分区。对人类特有的认知能力特别重要的是额极皮层（布罗德曼10区），相对于猿类大脑的其他部分，人类的额极皮层要大得多。这个大脑区域的具体功能仍然知之甚少，但最近的神经成像研究表明，它可能在探索和处理次要目标时记住目标。在这里，我们表明，额极皮层的损害程度预测在多个目标的管理障碍。这一结果表明，额极皮层的完整性对于执行要求受试者在处理次要目标的同时保持主要目标的任务是必要的，这种能力对于复杂的人类认知能力至关重要。这些结果提供了重要的新见解有关复杂的人类认知，如规划和多任务的大脑基础。
A major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of particular importance to the cognitive capacities that are uniquely human is the fronto-polar cortex (Brodmann's area 10), which is disproportionally larger in humans relative to the rest of the brain than it is in the ape's brain. The specific function of this brain region remains poorly understood, but recent neuroimaging studies have proposed that it may hold goals in mind while exploring and processing secondary goals. Here we show that the extent of damage to the fronto-polar cortex predicts impairment in the management of multiple goals. This result reveals that the integrity of the fronto-polar cortex is necessary to perform tasks that require subjects to maintain a primary goal in mind while processing secondary goals, an ability which is crucial for complex human cognitive abilities. These results provide important new insights concerning the cerebral basis of complex human cognition such as planning and multitasking.
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影响因子：
64.8
作者：
Daw, Nathaniel D.;O'Doherty, John P.;Dayan, Peter;Seymour, Ben;Dolan, Raymond J.
通讯作者：
Dolan, Raymond J.
影响因子：
3.7
作者：
Dreher, JC;Grafman, J
通讯作者：
Grafman, J
DOI：
10.1073/pnas.96.4.1794
发表时间：
1999-02-16
影响因子：
11.1
作者：
Düzel, E;Cabeza, R;Tulving, E
通讯作者：
Tulving, E
影响因子：
16.2
作者：
Koechlin, E;Danek, A;Grafman, J
通讯作者：
Grafman, J
影响因子：
2.9
作者：
Green, Adam E.;Fugelsang, Jonathan A.;Dunbar, Kevin N.
通讯作者：
Dunbar, Kevin N.