Cigarette smoking, cadmium exposure, and zinc intake on obstructive lung disorder.
Cigarette smoking, cadmium exposure, and zinc intake on obstructive lung disorder.
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DOI：
10.1186/1465-9921-11-53
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发表时间：
2010-05-09
影响因子：
5.8
通讯作者：
Lin JW
中科院分区：
文献类型：
--
作者：
Lin YS;Caffrey JL;Chang MH;Dowling N;Lin JW
这项研究通过与香烟烟雾中的主要毒物之一镉的相互作用，研究了锌摄入量是否与吸烟引起的阻塞性肺疾病的风险降低有关。数据来自第三次全国健康与营养检查调查的6726名年龄在40岁以上的受试者。肺活量测定仪测定1秒用力呼气量(FEV1)和用力肺活量(FVC)。使用性别、种族和年龄特定的方程来计算正常下限(LLN)，以定义阻塞性肺疾病：观察到的FEV1/FVC比率和FEV1低于各自的LLN。采用问卷调查法进行锌摄入量评估。应用Logistic回归分析来研究感兴趣的关联。分析表明，无论吸烟状况如何，低锌摄入量的人都会增加阻塞性肺疾病的患病率。调整后，锌摄入量最低的四分位数的受试者患肺部疾病的几率大约是最高三分位数的受试者的1.9倍(优势比=1.89，95%可信区间=1.22-2.93)。校正尿镉因素后，吸烟对肺功能的影响显著降低。锌/镉比率(对数转换)和呼吸风险之间的保护性关联表明，锌可能通过改变镉的影响在吸烟相关的肺部疾病中发挥作用。虽然锌摄入量与阻塞性肺疾病的风险较低有关，但戒烟和/或预防吸烟的作用可能更重要，因为它们对呼吸风险的影响要大得多。未来的研究有必要探索锌可以改变吸烟相关肺部疾病的机制。
This study examined whether zinc intake was associated with lower risk of smoking-induced obstructive lung disorder through interplay with cadmium, one of major toxicants in cigarette smoke. Data were obtained from a sample of 6,726 subjects aged 40+ from the Third National Health and Nutrition Examination Survey. The forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were measured using spirometry. Gender-, ethnicity-, and age-specific equations were used to calculate the lower limit of normal (LLN) to define obstructive lung disorder as: observed FEV1/FVC ratio and FEV1 below respective LLN. Zinc intake was assessed by questionnaire. Logistic regression analysis was applied to investigate the associations of interest. The analyses showed that an increased prevalence of obstructive lung disorder was observed among individuals with low zinc intake regardless of smoking status. The adjusted odds of lung disorder are approximately 1.9 times greater for subjects in the lowest zinc-intake tertile than those in the highest tertile (odds ratio = 1.89, 95% confidence interval = 1.22-2.93). The effect of smoking on lung function decreased considerably after adjusting for urinary cadmium. Protective association between the zinc-to-cadmium ratio (log-transformed) and respiratory risk suggests that zinc may play a role in smoking-associated lung disorder by modifying the influence of cadmium. While zinc intake is associated with lower risk of obstructive lung disorder, the role of smoking cession and/or prevention are likely to be more important given their far greater effect on respiratory risk. Future research is warranted to explore the mechanisms by which zinc could modify smoking-associated lung disease.
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影响因子：
5.8
作者：
Lin YS;Caffrey JL;Chang MH;Dowling N;Lin JW
通讯作者：
Lin JW
DOI：
10.1164/rccm.200607-969oc
发表时间：
2007-04-15
影响因子：
24.7
作者：
Jiang, Rui;Paik, David C.;Barr, R. Graham
通讯作者：
Barr, R. Graham
DOI：
10.1186/1476-9255-6-19
发表时间：
2009-06-12
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Kundu S;Sengupta S;Chatterjee S;Mitra S;Bhattacharyya A
通讯作者：
Bhattacharyya A
影响因子：
5.6
作者：
Lin, Yu-Sheng;Rathod, Dhruv;Caffrey, James J.
通讯作者：
Caffrey, James J.
影响因子：
8.3
作者：
Jin, TY;Nordberg, G;Bernard, A
通讯作者：
Bernard, A