Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis.
Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis.
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DOI：
10.1016/j.pacs.2023.100454
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发表时间：
2023-03
期刊：
影响因子：
7.9
通讯作者：
Ntziachristos, Vasilis
中科院分区：
文献类型：
--
作者：
Fasoula, Nikolina-Alexia;Karlas, Angelos;Prokopchuk, Olga;Katsouli, Nikoletta;Bariotakis, Michail;Liapis, Evangelos;Goetz, Anna;Kallmayer, Michael;Reber, Josefine;Novotny, Alexander;Friess, Helmut;Ringelhan, Marc;Schmid, Roland;Eckstein, Hans -Henning;Hofmann, Susanna;Ntziachristos, Vasilis
关键词：
肝脂肪变性的特征是肝内脂质积聚，如果不治疗可能导致不可逆的肝损伤。在这里，我们研究多光谱光声断层扫描（MSOT）是否可以提供肝脏脂质含量的无标记检测，通过分析930 nm左右的光谱区域，脂质特征性吸收，实现肝脂肪变性的非侵入性表征。在一项初步研究中，我们应用MSOT测量了5名肝脂肪变性患者和5名健康志愿者的肝脏和周围组织，显示患者在930 nm处的吸收明显更高，而两组的皮下脂肪组织没有观察到显著差异。我们用高脂饮食（HFD）和常规食物饮食（CD）喂养的小鼠中的相应MSOT测量进一步证实了人类观察结果。本研究介绍了MSOT作为一种潜在的非侵入性和便携式技术，用于在临床环境中检测/监测肝脏脂肪变性，为更大规模的研究提供了依据。
Hepatic steatosis is characterized by intrahepatic lipid accumulation and may lead to irreversible liver damage if untreated. Here, we investigate whether multispectral optoacoustic tomography (MSOT) can offer label-free detection of liver lipid content to enable non-invasive characterization of hepatic steatosis by analyzing the spectral region around 930 nm, where lipids characteristically absorb. In a pilot study, we apply MSOT to measure liver and surrounding tissues in five patients with liver steatosis and five healthy volunteers, revealing significantly higher absorptions at 930 nm in the patients, while no significant difference was observed in the subcutaneous adipose tissue of the two groups. We further corroborated the human observations with corresponding MSOT measurements in high fat diet (HFD) - and regular chow diet (CD)-fed mice. This study introduces MSOT as a potential non-invasive and portable technique for detecting/monitoring hepatic steatosis in clinical settings, providing justification for larger studies.
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