Multicompartmental non-invasive sensing of postprandial lipemia in humans with multispectral optoacoustic tomography.
Multicompartmental non-invasive sensing of postprandial lipemia in humans with multispectral optoacoustic tomography.
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DOI：
10.1016/j.molmet.2021.101184
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发表时间：
2021-05
影响因子：
8.1
通讯作者：
Ntziachristos V
中科院分区：
文献类型：
--
作者：
Fasoula NA;Karlas A;Kallmayer M;Milik AB;Pelisek J;Eckstein HH;Klingenspor M;Ntziachristos V
餐后血脂分析（PLP）是心脏代谢疾病的风险指标，基于餐后数小时内的频繁采血，这种方法具有侵入性且不方便。非侵入性PLP可能提供了一种替代的传播人体监测。在此，我们研究了临床多光谱光声断层扫描（MSOT）在人体血管和软组织中通过直接脂质传感进行无创、无标记PLP的应用。4例（n = 4）受试者（3例女性和1例男性，年龄：28 ± 7岁）入组当前初步研究。我们纵向测量了动脉，静脉，骨骼肌和脂肪组织的脂质信号，所有参与者在30分钟的时间间隔为6小时后，口服高脂肪餐。光声脂质信号分析显示，餐后约4 h动脉内平均增加63.4%，约3 h静脉内增加83.9%，约3 h肌肉内增加120.8%，约4 h皮下脂肪增加32.8%。MSOT提供了研究脂质代谢的潜力，通过无标记、非侵入性检测与心脏代谢疾病有关的组织生物标志物，可能导致新的诊断和预防策略。MSOT提供餐后脂质动力学的非侵入性和无标记成像。MSOT提供了高分辨率的体内多室脂质可视化。临床手持MSOT是一种灵活的、高度便携的分子成像工具。
Postprandial lipid profiling (PLP), a risk indicator of cardiometabolic disease, is based on frequent blood sampling over several hours after a meal, an approach that is invasive and inconvenient. Non-invasive PLP may offer an alternative for disseminated human monitoring. Herein, we investigate the use of clinical multispectral optoacoustic tomography (MSOT) for non-invasive, label-free PLP via direct lipid-sensing in human vasculature and soft tissues. Four (n = 4) subjects (3 females and 1 male, age: 28 ± 7 years) were enrolled in the current pilot study. We longitudinally measured the lipid signals in arteries, veins, skeletal muscles, and adipose tissues of all participants at 30-min intervals for 6 h after the oral consumption of a high-fat meal. Optoacoustic lipid-signal analysis showed on average a 63.4% intra-arterial increase at ~ 4 h postprandially, an 83.9% intra-venous increase at ~ 3 h, a 120.8% intra-muscular increase at ~ 3 h, and a 32.8% subcutaneous fat increase at ~ 4 h. MSOT provides the potential to study lipid metabolism that could lead to novel diagnostics and prevention strategies by label-free, non-invasive detection of tissue biomarkers implicated in cardiometabolic diseases. MSOT provides non-invasive and label-free imaging of postprandial lipid dynamics. MSOT provides high-resolution multicompartmental lipid visualizations in vivo. Clinical hand-held MSOT is a flexible and highly-portable molecular imaging tool.
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影响因子：
10.6
作者：
Chowdhury, Kaushik Basak;Prakash, Jaya;Ntziachristos, Vasilis
通讯作者：
Ntziachristos, Vasilis
影响因子：
7.9
作者：
Chlis NK;Karlas A;Fasoula NA;Kallmayer M;Eckstein HH;Theis FJ;Ntziachristos V;Marr C
通讯作者：
Marr C
影响因子：
5.9
作者：
Klop B;Elte JW;Cabezas MC
通讯作者：
Cabezas MC
影响因子：
5.6
作者：
Castelli, W P;Anderson, K;Levy, D
通讯作者：
Levy, D
影响因子：
37.8
作者：
Langsted, Anne;Freiberg, Jacob J.;Nordestgaard, Borge G.
通讯作者：
Nordestgaard, Borge G.