A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow.
A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow.
复制标题
DOI：
10.1038/s41467-018-02900-1
复制
发表时间：
2018-02-14
影响因子：
16.6
通讯作者：
Relman DA
中科院分区：
文献类型：
--
作者：
Proctor DM;Fukuyama JA;Loomer PM;Armitage GC;Lee SA;Davis NM;Ryder MI;Holmes SP;Relman DA
微生物群落的空间和时间模式提供了对塑造它们的力量，它们在健康和疾病中的功能和作用的见解。在这里，我们使用空间和生态统计学来分析唾液在使用>9000个牙齿和粘膜样本构建人类口腔细菌群落中的作用。我们发现，无论组织类型（牙齿，牙槽粘膜，角质化牙龈，或颊粘膜），表面相关的细菌群落变化沿着生态梯度从前面到后面的嘴，并在暴露的牙齿表面，梯度是明显的舌面相比，颊面。此外，我们的数据表明，这种梯度是减弱的个人与低唾液流量由于干燥综合征。两者合计，我们的研究结果表明，唾液流影响微生物群落的空间组织和地理模式可能是有用的了解宿主的生理过程和预测疾病。口腔微生物群落是研究微生物群结构变异机制的绝佳场所。在这里，作者使用空间和生态分析来检查9000多个牙齿和粘膜微生物群样本。他们发现唾液在构建口腔细菌群落中起着关键作用。
Spatial and temporal patterns in microbial communities provide insights into the forces that shape them, their functions and roles in health and disease. Here, we used spatial and ecological statistics to analyze the role that saliva plays in structuring bacterial communities of the human mouth using >9000 dental and mucosal samples. We show that regardless of tissue type (teeth, alveolar mucosa, keratinized gingiva, or buccal mucosa), surface-associated bacterial communities vary along an ecological gradient from the front to the back of the mouth, and that on exposed tooth surfaces, the gradient is pronounced on lingual compared to buccal surfaces. Furthermore, our data suggest that this gradient is attenuated in individuals with low salivary flow due to Sjögren’s syndrome. Taken together, our findings imply that salivary flow influences the spatial organization of microbial communities and that biogeographical patterns may be useful for understanding host physiological processes and for predicting disease. Oral microbial communities are excellent sites for examining the mechanisms of structural variation in the microbiota. Here, the authors use spatial and ecological analysis to examine over 9000 dental and mucosal microbiota samples. They find that saliva plays a key role in structuring bacterial communities in the mouth.
登录
查看更多内容
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
15.5
作者：
Gorvitovskaia A;Holmes SP;Huse SM
通讯作者：
Huse SM
DOI：
10.1073/pnas.1424409112
发表时间：
2015-04-28
影响因子：
11.1
作者：
Bouslimani, Amina;Porto, Carla;Dorrestein, Pieter C.
通讯作者：
Dorrestein, Pieter C.
DOI：
10.1073/pnas.1502875112
发表时间：
2015-09-01
影响因子：
11.1
作者：
DiGiulio, Daniel B.;Callahan, Benjamin J.;Relman, David A.
通讯作者：
Relman, David A.
影响因子：
3.5
作者：
Haffajee, A. D.;Teles, R. P.;Socransky, S. S.
通讯作者：
Socransky, S. S.