Sleep evoked delta frequency responses show a linear decline in amplitude across the adult lifespan.
Sleep evoked delta frequency responses show a linear decline in amplitude across the adult lifespan.
复制标题
睡眠唤起的三角洲频率反应显示，整个成人寿命的振幅线性下降。
DOI：
10.1016/j.neurobiolaging.2008.06.003
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发表时间：
2010-05
影响因子：
4.2
通讯作者：
Trinder, John
中科院分区：
文献类型：
--
作者：
Colrain, Ian M.;Crowley, Kate E.;Nicholas, Christian L.;Afifi, Lamia;Baker, Fiona C.;Padilla, Mayra;Turlington, Sharon R.;Trinder, John
衰老与睡眠的许多变化有关，其中最突出的是慢波睡眠的减少。这种现象的传统测量方法依赖于自发活动，通常会混淆三角波的入射和振幅。在睡眠中测量诱发的k -复合体，可以从平均k -复合体波形中单独评估发生率和振幅。本研究描述了70名年龄在19至78岁之间的正常健康男性和女性的数据。k -复合物是用短的听觉音调引起的，并从头皮中线阵列记录。随着年龄的增长，平均波形的N550分量（代表k复合体的振幅）的振幅显著降低，线性回归分析表明，大约50%的方差是由年龄引起的。诱导k复合物的能力虽小但仍显著降低。这些数据强调了诱发k复合物作为男性和女性大脑衰老敏感标记物的效用。
Aging is associated with many changes in sleep, with one of the most prominent being a reduction in slow wave sleep. Traditional measures of this phenomenon rely on spontaneous activity and typically confound the incidence and amplitude of delta waves. The measurement of evoked K-complexes during sleep, enable separate assessment of incidence and amplitude taken from the averaged K-complex waveform. The present study describes data from 70 normal healthy men and women aged between 19 and 78 years. K-complexes were evoked using short auditory tones and recorded from a midline array of scalp sites. Significant reductions with age were seen in the amplitude of the N550 component of the averaged waveform, which represents the amplitude of the K-complex, with linear regression analysis indicating approximately 50% of the variance was due to age. Smaller, yet still significant reductions were seen in the ability to elicit K-complexes. The data highlight the utility of evoked K-complexes as a sensitive marker of brain aging in men and women.
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DOI：
10.1176/jnp.2006.18.4.529
发表时间：
2006-09-01
影响因子：
2.9
作者：
Goeder, Robert;Aldenhoff, Josef Bernd;Fritzer, Gunther
通讯作者：
Fritzer, Gunther
影响因子：
2.3
作者：
Afifi, L;Guilleminault, C;Colrain, IM
通讯作者：
Colrain, IM
影响因子：
5.7
作者：
Dang-Vu, TT;Desseilles, M;Peigneux, P
通讯作者：
Peigneux, P
影响因子：
4.7
作者：
Crowley, K;Trinder, J;Colrain, IM
通讯作者：
Colrain, IM
影响因子：
5.6
作者：
Feinberg, I;Campbell, IG
通讯作者：
Campbell, IG