Intrinsic limbic and paralimbic networks are associated with criminal psychopathy.
Intrinsic limbic and paralimbic networks are associated with criminal psychopathy.
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DOI：
10.1002/hbm.22037
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发表时间：
2013-08
影响因子：
4.8
通讯作者：
Calhoun, Vince D.
中科院分区：
文献类型：
--
作者：
Juarez, Michelle;Kiehl, Kent A.;Calhoun, Vince D.
关键词：
精神病是一种与决策障碍、同理心和冲动有关的人格障碍。最近的脑成像研究表明，精神病与边缘/边缘旁脑区的异常有关。到目前为止，还没有研究使用独立成分分析(ICA)来检查患有精神病的成年人的脑功能连通性。在这里，我们测试了关于成年囚犯边缘连接的假设，并根据精神病评分进行了分层。采用《野兔精神病检查表-修订版》对102名监狱服刑人员进行评定。FMRI数据是在受试者执行听觉目标检测“古怪”任务时收集的。使用ICA组对fMRI数据进行分析，以确定对古怪任务的反应与精神病评分相关的功能网络。与精神病显著相关的组件包括默认模式网络、额顶组件和视觉/后扣带组件。调制趋势与额顶和视觉/后扣带回网络中的因子2(冲动性)和PCL-R总分以及默认模式网络中的因子1(情感)得分密切相关。在观察到的调制趋势中，后扣带区起了显著作用。与边缘/边缘异常与精神病相关的假设一致，调制趋势与PCL-R得分密切相关。有强有力的证据表明，后扣带回与异常的功能连接有关，与精神变态症状的表现有关。未来的研究比较精神变态受试者中与后扣带核相关的功能趋势，可能会为这种疾病的表现提供进一步的洞察。
Psychopathy is a personality disorder associated with impairments in decision-making, empathy, and impulsivity. Recent brain imaging studies suggest that psychopathy is associated with abnormalities in limbic/paralimbic brain regions. To date, no studies have examined functional brain connectivity measures using independent component analyses (ICA) in adults with psychopathy. Here, we test hypotheses regarding paralimbic connectivity in adult incarcerated individuals stratified by psychopathy scores. One hundred and two prison inmates were rated using the Hare Psychopathy Checklist-Revised (PCL-R). FMRI data were collected while subjects performed an auditory target detection “oddball” task. FMRI data were analyzed using group ICA to identify functional networks responding to the oddball task correlating with psychopathy scores. Components demonstrating significant correlations with psychopathy included a default mode network, a frontoparietal component, and a visual/posterior cingulate component. Modulation trends correlated strongly with factor 2 (impulsivity) and total PCL-R scores in the frontoparietal and visual/posterior cingulate networks, and with factor 1 (affective) scores within the default mode network. The posterior cingulate region factored significantly in the modulation trends observed. Consistent with the hypothesis of limbic/paralimbic abnormalities associated with psychopathy, modulation trends correlated strongly with PCL-R scores. There is strong evidence to implicate the posterior cingulate in aberrant functional connectivity associated with the manifestation of psychopathic symptoms. Future investigations comparing functional trends associated with the posterior cingulate in psychopathic subjects may provide further insight into the manifestation of this disorder.
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影响因子：
5.7
作者：
Kiehl, KA;Stevens, MC;Liddle, PF
通讯作者：
Liddle, PF
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
5.7
作者：
Bentley, P;Vuilleumier, P;Dolan, RJ
通讯作者：
Dolan, RJ
影响因子：
5.7
作者：
Calhoun, VD;Adali, T;Pearlson, GD
通讯作者：
Pearlson, GD
影响因子：
5.7
作者：
Calhoun VD;Liu J;Adali T
通讯作者：
Adali T