Central and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability.
Central and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability.
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对成瘾风险和复发脆弱性的压力反应的中央和周围生物标志物。
DOI：
10.1016/j.molmed.2017.12.010
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发表时间：
2018-03
影响因子：
13.6
通讯作者：
Sinha R
中科院分区：
文献类型：
--
作者：
Milivojevic V;Sinha R
物质使用障碍（sud）的特点是临床症状的异质性和治疗后的高复发率。在这里，我们描述了与sud病理生理相关的特定外周和中枢应激反应。我们概述了潜在的应激反应措施，包括HPA轴标记，自主反应和中枢结构和功能脑改变，这些可能被用作sud的推定生物标志物。我们假设应激反应可以预测sud的发展及其高复发性。我们研究了它们作为候选生物标志物的潜力，以及在开发和实施它们作为预防和治疗sud的生物标志物方面存在的挑战。
Substance use disorders (SUDs) are marked by heterogeneity in clinical symptomatology and high relapse rates following treatment. Here, we describe specific peripheral and central stress responses associated with the pathophysiology of SUDs. We outline potential stress response measures including HPA axis markers, autonomic responses and central structural and functional brain alterations that could be exploited as putative biomarkers in SUDs. We posit that stress responses can be predictive of both the development of SUDs and their high relapsing nature. We examine their potential as candidate biomarkers, as well as the remaining challenges in developing and implementing them as biomarkers for the prevention and treatment of SUDs.
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影响因子：
10.6
作者：
Ansell, Emily B.;Rando, Kenneth;Tuit, Keri;Guarnaccia, Joseph;Sinha, Rajita
通讯作者：
Sinha, Rajita
影响因子：
3.7
作者：
Fox, HC;Talih, M;Sinha, R
通讯作者：
Sinha, R
DOI：
10.1016/j.jaac.2017.06.006
发表时间：
2017-09-01
影响因子：
13.3
作者：
Carliner, Hannah;Gary, Dahsan;Keyes, Katherine M.
通讯作者：
Keyes, Katherine M.
影响因子：
3.4
作者：
Ashare, Rebecca L.;Sinha, Rajita;McKee, Sherry A.
通讯作者：
McKee, Sherry A.
DOI：
10.1111/j.1530-0277.2011.01452.x
发表时间：
2011-06
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Durazzo TC;Tosun D;Buckley S;Gazdzinski S;Mon A;Fryer SL;Meyerhoff DJ
通讯作者：
Meyerhoff DJ