Cellular prognostic markers in hepatitis-related hepatocellular carcinoma.

Cellular prognostic markers in hepatitis-related hepatocellular carcinoma.
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DOI:
10.1186/s13027-018-0183-8
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发表时间:
2018
影响因子:
3.7
通讯作者:
Buonaguro L
Buonaguro L
中科院分区:
医学3区
文献类型:
--
作者:
Petrizzo A;Mauriello A;Tornesello ML;Buonaguro FM;Tagliamonte M;Buonaguro L

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肝细胞癌(HCC)是最常见的原发性肝脏恶性肿瘤,约占全球新诊断癌症的6%。此外,它是男性和女性癌症死亡的第三和第五大原因。HBV和HCV慢性感染是HCC的主要危险因素。根据肝脏疾病的程度和严重程度,HCC的治疗采用了一系列治疗方法。从这个角度来看,预后评估是HCC患者正确治疗的关键一步。然而,HCC患者在同一疾病阶段的临床结局可能有显著差异。因此,人们做出了许多努力来定义具有更精确预后价值的新参数,并且寻找HCC预后标志物的势头正在增强。本综述旨在提供HCC细胞预后标志物的最新进展。
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and accounts for about 6% of all new cancers diagnosed worldwide. Moreover, it is the third and the fifth leading cause of death from cancer in men and women, respectively. HBV and HCV chronic infection is the main risk factor for HCC. A range of therapies are used in the management of HCC according to the extent and severity of liver disease. In this perspective, evaluation of prognosis represents a crucial step for proper management of HCC patients. However, the clinical outcome can be significantly different in HCC patients within the same stage of disease. Therefore, many efforts have been made to define new parameters with more precise prognostic value, and the search for HCC prognostic markers is gaining momentum. The present review aims at providing an update on cellular prognostic markers for HCC.
结直肠癌瘤内中性粒细胞增多与恶性表型密切相关,可预测患者的不良预后。
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