Robust data-driven identification of risk factors and their interactions: A simulation and a study of parental and demographic risk factors for schizophrenia.
Robust data-driven identification of risk factors and their interactions: A simulation and a study of parental and demographic risk factors for schizophrenia.
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DOI：
10.1002/mpr.1834
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发表时间：
2020-12
影响因子：
3.1
通讯作者：
Brown AS
中科院分区：
文献类型：
--
作者：
Gyllenberg D;McKeague IW;Sourander A;Brown AS
Few interactions between risk factors for schizophrenia have been replicated, but fitting all such interactions is difficult due to high‐dimensionality. Our aims are to examine significant main and interaction effects for schizophrenia and the performance of our approach using simulated data. We apply the machine learning technique elastic net to a high‐dimensional logistic regression model to produce a sparse set of predictors, and then assess the significance of odds ratios (OR) with Bonferroni‐corrected p‐values and confidence intervals (CI). We introduce a simulation model that resembles a Finnish nested case–control study of schizophrenia which uses national registers to identify cases (n = 1,468) and controls (n = 2,975). The predictors include nine sociodemographic factors and all interactions (31 predictors). In the simulation, interactions with OR = 3 and prevalence = 4% were identified with <5% false positive rate and ≥80% power. None of the studied interactions were significantly associated with schizophrenia, but main effects of parental psychosis (OR = 5.2, CI 2.9–9.7; p < .001), urbanicity (1.3, 1.1–1.7; p = .001), and paternal age ≥35 (1.3, 1.004–1.6; p = .04) were significant. We have provided an analytic pipeline for data‐driven identification of main and interaction effects in case–control data. We identified highly replicated main effects for schizophrenia, but no interactions.
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通讯作者：
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通讯作者：
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