Treatment of Argentine hemorrhagic fever.
Treatment of Argentine hemorrhagic fever.
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DOI：
10.1016/j.antiviral.2007.10.010
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发表时间：
2008-04
影响因子：
7.6
通讯作者：
Sánchez Z
中科院分区：
文献类型：
--
作者：
Enria DA;Briggiler AM;Sánchez Z
阿根廷出血热（AHF）是一种啮齿动物传播的疾病，由沙粒病毒朱宁引起，是阿根廷潮湿的潘帕斯草原的地方病。自20世纪50年代出现以来，AHF的发病率很高，未经治疗的病死率在15%至30%之间。减毒活疫苗的使用显著降低了AHF的发病率。目前的特异性治疗包括在疾病的前驱期输注规定剂量的中和抗体的免疫血浆。然而，由于目前AHF早期检测的困难，需要替代形式的治疗，这与其发病率的降低、维持足够的免疫血浆储备的困难以及对进展到神经出血期的重症患者缺乏有效的治疗有关。在保证供应的前提下，利巴韦林可作为免疫血浆的替代品。还应考虑免疫球蛋白或单克隆抗体。新的治疗选择，如那些正在开发的全身炎症综合征也应评估严重形式的AHF。
Argentine hemorrhagic fever (AHF) is a rodent-borne illness caused by the arenavirus Junin that is endemic to the humid pampas of Argentina. AHF has had significant morbidity since its emergence in the 1950s, with a case-fatality rate of the illness without treatment between 15% and 30%. The use of a live attenuated vaccine has markedly reduced the incidence of AHF. Present specific therapy involves the transfusion of immune plasma in defined doses of neutralizing antibodies during the prodromal phase of illness. However, alternative forms of treatment are called for due to current difficulties in early detection of AHF, related to its decrease in incidence, troubles in maintaining adequate stocks of immune plasma, and the absence of effective therapies for severely ill patients that progress to a neurologic–hemorrhagic phase. Ribavirin might be a substitute for immune plasma, provided that the supply is guaranteed. Immune immunoglobulin or monoclonal antibodies should also be considered. New therapeutic options such as those being developed for systemic inflammatory syndromes should also be valuated in severe forms of AHF.
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影响因子：
168.9
作者：
ENRIA, DA;BRIGGILER, AM;MAIZTEGUI, JI
通讯作者：
MAIZTEGUI, JI
影响因子：
4.9
作者：
Gowen, BB;Barnard, DL;Sidwell, RW
通讯作者：
Sidwell, RW
影响因子：
158.5
作者：
DEBRACCO, MME;RIMOLDI, MT;ARANA, RM
通讯作者：
ARANA, RM
影响因子：
158.5
作者：
GROSS, PAM;GITLIN, D;JANEWAY, CA
通讯作者：
JANEWAY, CA
影响因子：
7.6
作者：
Bolken TC;Laquerre S;Zhang Y;Bailey TR;Pevear DC;Kickner SS;Sperzel LE;Jones KF;Warren TK;Amanda Lund S;Kirkwood-Watts DL;King DS;Shurtleff AC;Guttieri MC;Deng Y;Bleam M;Hruby DE
通讯作者：
Hruby DE