Functional connectivity change between posterior cingulate cortex and ventral attention network relates to the impairment of orientation for time in Alzheimer’s disease patients
Functional connectivity change between posterior cingulate cortex and ventral attention network relates to the impairment of orientation for time in Alzheimer’s disease patients
复制标题
阿尔茨海默病患者后扣带皮层和腹侧注意网络之间的功能连接变化与时间定向障碍有关
DOI：
10.1007/s11682-018-9860-x
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发表时间：
2018
影响因子：
3.2
通讯作者：
Kira Jun-ichi
中科院分区：
文献类型：
--
作者：
Yamashita Ken-ichiro;Uehara Taira;Prawiroharjo Pukovisa;Yamashita Koji;Togao Osamu;Hiwatashi Akio;Taniwaki Yoshihide;Utsunomiya Hidetsuna;Matsushita Takuya;Yamasaki Ryo;Kira Jun-ichi
阿尔茨海默病（AD）患者表现出各种认知功能障碍，包括时间定向（OT）障碍。OT损伤的脑区仍有待阐明。先前的单光子发射计算机断层扫描研究表明后扣带回皮质（PCC）灌注不足与OT恶化有关。在这项研究中，我们研究了全脑功能连接的变化，PCC使用静息态功能磁共振成像。根据简易精神状态检查子量表的平均OT评分，对OT差或OT好的AD患者进行了基于体素的PCC功能连接分析。与OT良好的AD组相比，OT不良的AD组的背侧额叶、侧顶叶和侧颞叶与右半球PCC的连通性降低。OT评分差异（OT-好减去OT-差）的减法连接图显示，右侧颞中回靠近颞顶交界处，是与PCC显著连接的区域。这些结果提示，右颞中回后部可能与PCC一起在OT中起重要作用，PCC与右腹侧注意网络的断开可能导致AD患者OT障碍。
Alzheimer’s disease (AD) patients exhibit various cognitive dysfunctions, including impairment of orientation for time (OT). The brain regions underlying OT impairment remain to be elucidated. A previous single-photon emission computed tomography study has indicated hypoperfusion of the posterior cingulate cortex (PCC) in relation to deterioration of OT. In this study, we investigated whole brain functional connectivity changes of PCC using resting-state functional magnetic resonance imaging. Voxel-based functional connectivity with PCC was analyzed in OT-poor or OT-good AD patients, classified according to the mean OT scores of the Mini-Mental State Examination subscale. The connectivities of dorsal frontal lobe, and lateral parietal and lateral temporal lobes with PCC in the right hemisphere were reduced in the OT-poor AD group compared with the OT-good AD group. A subtraction connectivity map of OT score differences (OT-good minus OT-poor) revealed the right middle temporal gyrus near the temporo-parietal junction as a significantly connected region with PCC. These results suggest that the right posterior part of the middle temporal gyrus may play an important role in OT in conjunction with PCC, and that disconnection between PCC and the right ventral attention network may cause OT disturbance in AD patients.
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影响因子：
11
作者：
BURNS, A;PHILPOT, MP;LEVY, R
通讯作者：
LEVY, R
临床神经心理学在阿尔茨海默病神经学诊断中的作用
影响因子：
6
作者：
H. Spinnler;S. Sala
通讯作者：
S. Sala
基于时间定向预测神经心理测试表现
DOI：
10.1080/13825580902741344
发表时间：
2009
期刊：
Aging, Neuropsychology, and Cognition
影响因子：
--
作者：
J. Ryan;Laura A. Glass;J. Bartels;C. Bergner;A. Paolo
通讯作者：
A. Paolo
使用 99mTc-HM-PAO 进行单光子发射断层扫描来研究痴呆症。
影响因子：
11
作者：
D. Neary;J. Snowden;R. Shields;A. Burjan;B. Northen;N. Macdermott;M. Prescott;H. Testa
通讯作者：
H. Testa
脑灌注 SPECT 三维立体定向表面投影改善阿尔茨海默病的诊断
影响因子：
2.6
作者：
N. Honda;K. Machida;T. Matsumoto;H. Matsuda;E. Imabayashi;J. Hashimoto;M. Hosono;Y. Inoue;K. Koizumi;S. Kosuda;T. Momose;Y. Mori;M. Oshima
通讯作者：
M. Oshima