RBC membrane biomechanics and Plasmodium falciparum invasion: probing beyond ligand-receptor interactions.
RBC membrane biomechanics and Plasmodium falciparum invasion: probing beyond ligand-receptor interactions.
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DOI：
10.1016/j.pt.2021.12.005
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发表时间：
2022-04
影响因子：
9.6
通讯作者：
Duraisingh MT
中科院分区：
文献类型：
--
作者：
Groomes PV;Kanjee U;Duraisingh MT
A critical step in malaria blood-stage infections is the invasion of red blood cells (RBCs) by merozoite forms of the Plasmodium parasite. Much progress has been made in defining the parasite ligands and host receptors that mediate this critical step. However, less well understood are the RBC biophysical determinants that influence parasite invasion. In this review we explore how Plasmodium falciparum merozoites interact with the RBC membrane during invasion to modulate RBC deformability and facilitate invasion. We further highlight RBC biomechanics-related polymorphisms that might have been selected for in human populations due to their ability to reduce parasite invasion. Such an understanding will reveal the translational potential of targeting host pathways affecting RBC biomechanical properties for the treatment of malaria.
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影响因子：
16.6
作者：
Dekel E;Yaffe D;Rosenhek-Goldian I;Ben-Nissan G;Ofir-Birin Y;Morandi MI;Ziv T;Sisquella X;Pimentel MA;Nebl T;Kapp E;Ohana Daniel Y;Karam PA;Alfandari D;Rotkopf R;Malihi S;Temin TB;Mullick D;Revach OY;Rudik A;Gov NS;Azuri I;Porat Z;Bergamaschi G;Sorkin R;Wuite GJL;Avinoam O;Carvalho TG;Cohen SR;Sharon M;Regev-Rudzki N
通讯作者：
Regev-Rudzki N
DOI：
10.4269/ajtmh.2006.75.597
发表时间：
2006-10-01
影响因子：
3.3
作者：
Benet, Ariadna;Khong, T. Yee;Cortes, Alfred
通讯作者：
Cortes, Alfred
影响因子：
3.1
作者：
Dankwa S;Chaand M;Kanjee U;Jiang RHY;Nobre LV;Goldberg JM;Bei AK;Moechtar MA;Grüring C;Ahouidi AD;Ndiaye D;Dieye TN;Mboup S;Weekes MP;Duraisingh MT
通讯作者：
Duraisingh MT
影响因子：
64.8
作者：
Malaria Genomic Epidemiology Network;Band G;Rockett KA;Spencer CC;Kwiatkowski DP
通讯作者：
Kwiatkowski DP
DOI：
10.1126/science.aaa3526
发表时间：
2015-05-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Egan ES;Jiang RH;Moechtar MA;Barteneva NS;Weekes MP;Nobre LV;Gygi SP;Paulo JA;Frantzreb C;Tani Y;Takahashi J;Watanabe S;Goldberg J;Paul AS;Brugnara C;Root DE;Wiegand RC;Doench JG;Duraisingh MT
通讯作者：
Duraisingh MT