Activity in primate visual cortex is minimally driven by spontaneous movements.
Activity in primate visual cortex is minimally driven by spontaneous movements.
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DOI：
10.1038/s41593-023-01459-5
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发表时间：
2023-11
影响因子：
25
通讯作者：
Nienborg, Hendrikje
中科院分区：
文献类型：
--
作者：
Talluri, Bharath Chandra;Kang, Incheol;Lazere, Adam;Quinn, Katrina R.;Kaliss, Nicholas;Yates, Jacob L.;Butts, Daniel A.;Nienborg, Hendrikje
生物体在自己运动的身体中处理感觉信息，这种想法被称为具体化。这个想法对发育神经科学、机器人和系统神经科学都很重要。支持具体化的机制尚不清楚，但一种表现可能是在小鼠中观察到的全脑神经调节，包括初级视觉皮层，由与任务无关的自发身体运动驱动。我们在猕猴（猕猴是人类视觉的灵长类动物模型）身上测试了这一假设，同时记录了视觉皮层的活动以及面部和身体的运动。我们还寻求使用与小鼠研究类似的方法进行直接比较。我们发现灵长类视觉皮层（V1， V2和V3/V3A）的活动与动物自身的运动有关，但这种调节在很大程度上可以通过运动对视网膜图像的影响来解释，即通过视觉输入的变化。这些结果表明，灵长类动物的视觉皮层很少受自发运动的驱动，可能反映了物种特有的感觉运动策略。在灵长类动物中，视觉皮层的活动不是由自发的身体运动驱动的。这些结果证实了灵长类动物视觉处理的功能专门化，与小鼠的研究结果相反，并强调了跨物种比较的重要性。
Organisms process sensory information in the context of their own moving bodies, an idea referred to as embodiment. This idea is important for developmental neuroscience, robotics and systems neuroscience. The mechanisms supporting embodiment are unknown, but a manifestation could be the observation in mice of brain-wide neuromodulation, including in the primary visual cortex, driven by task-irrelevant spontaneous body movements. We tested this hypothesis in macaque monkeys (Macaca mulatta), a primate model for human vision, by simultaneously recording visual cortex activity and facial and body movements. We also sought a direct comparison using an analogous approach to those used in mouse studies. Here we found that activity in the primate visual cortex (V1, V2 and V3/V3A) was associated with the animals’ own movements, but this modulation was largely explained by the impact of the movements on the retinal image, that is, by changes in visual input. These results indicate that visual cortex in primates is minimally driven by spontaneous movements and may reflect species-specific sensorimotor strategies. In primates, activity in the visual cortex is not driven by spontaneous body movements. These results confirm the functional specialization of primate visual processing, in contrast with findings in mice, and highlight the importance of cross-species comparisons.
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影响因子：
16.2
作者：
Bennett C;Arroyo S;Hestrin S
通讯作者：
Hestrin S
影响因子：
3.5
作者：
Eastman KM;Huk AC
通讯作者：
Huk AC
DOI：
10.1177/1073858418805427
发表时间：
2019-08
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Drew PJ;Winder AT;Zhang Q
通讯作者：
Zhang Q
影响因子：
9.2
作者：
Erisken, Sinem;Vaiceliunaite, Agne;Busse, Laura
通讯作者：
Busse, Laura
影响因子：
5.3
作者：
Gibaldi, Agostino;Banks, Martin S.
通讯作者：
Banks, Martin S.