IL-10, IL-6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight infants.
IL-10, IL-6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight infants.
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DOI：
10.1186/1741-7015-4-10
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发表时间：
2006-04-12
期刊：
影响因子：
9.3
通讯作者：
Yanamandra K
中科院分区：
文献类型：
--
作者：
Baier RJ;Loggins J;Yanamandra K
宿主先天免疫系统中的遗传变异可能在决定发生感染的风险以及感染结果方面发挥作用。对293例极低出生体重(VLBW)新生儿进行了IL-6-174 G/C、IL-10-1082 G/A和CD14-260 C/T单核苷酸多态性(SNPs)基因分型，对293例(其中非洲裔233例，高加索57例，西班牙裔3例)极低出生体重(VLBW)新生儿的感染并发症进行了回顾性分析。IL-6-174C等位基因与再生障碍性贫血(AA)婴儿晚期血流感染(BSI)发生率增加相关，但与高加索婴儿无关。在携带C等位基因的AA婴儿中，晚期BSI的发生率为20/29(69%)，而纯合子GG婴儿为94/204(46%)(RR2.6，95%CI：1.1~6.0，P=0.021)。IL-10-1082A等位基因与晚期BSI的发生率增加相关。GG型14例(35%)，GA型71例(49%)，AA型63例(58%)(P=0.036)。携带A等位基因(AA或GA等位基因)的婴儿迟发性高血压的发生率为134253(53%)，而纯合子GG婴儿为14/40(35%)(RR2.1，95%CI：1.04~4.19，P=0.035)。CD14-260C/T单核苷酸多态性并不改变呼吸机治疗的极低出生体重儿发生BSI的总体风险。TT型组多发脑出血(CC：17%，CT：11%，TT：30%，P=0.022)。这是由于TT型对AA婴儿多发性BSI的显著影响(CC：15%，CT：11%，TT：39%，P=0.003)。IL-6-174 G/C、IL-10-1082 G/A和CD14-260 C/T单核苷酸多态可能改变呼吸机支持下极低出生体重儿发生BSI的危险性。
Genetic variation in the innate immune system of the host may play a role in determining the risk of developing infection, as well as outcome from infection. Infectious complications were retrospectively determined in 293 (233 African-American (AA), 57 Caucasian and 3 Hispanic) mechanically ventilated very low birth weight (VLBW) infants (<1500 grams at birth) who were genotyped for the IL-6 -174 G/C, IL-10 -1082 G/A and CD14 -260 C/T single nucleotide polymorphisms (SNPs). The IL-6 -174C allele was associated with an increased incidence of late blood stream infection (BSI) in AA but not Caucasian infants. In AA infants with the C allele the incidence of late BSI was 20/29 (69%) compared to 94/204 (46%) in homozygous GG infants (RR 2.6, 95% CI: 1.1–6.0, p = 0.021). The IL-10 -1082A allele was associated with an increased incidence of late BSI. One or more episodes of late BSI developed in 14 (35%) of 40 infants with the GG genotype, 71 (49%) of 145 infants with the GA genotype and 63 (58%) of 108 infants with the AA genotype (p = 0.036). Infants with the A allele (AA or GA genotypes) had an incidence of late BSI that was 134/253 (53%) compared to 14/40 (35%) in homozygous GG infants (RR 2.1, 95% CI: 1.04–4.19, p = 0.035). The CD14 -260 C/T SNP did not alter the overall risk for BSI in ventilated VLBW infants. Multiple BSI episodes were more common in the TT genotype group (CC: 17%, CT: 11%, TT: 30%, p = 0.022). This effect was due to the strong effect of the TT genotype on the incidence of multiple BSI in AA infants (CC: 15%, CT: 11%, TT: 39%, p = 0.003). The IL-6 -174 G/C, IL-10 -1082 G/A and CD14 -260 C/T SNPs may alter risk for BSI in ventilated VLBW infants.
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