Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen.
Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen.
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DOI：
10.1016/j.schres.2009.06.022
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发表时间：
2009-09
影响因子：
4.5
通讯作者：
Buchsbaum, Monte S.
中科院分区：
文献类型：
--
作者：
Mitelman, Serge A.;Canfield, Emily L.;Chu, King-Wai;Brickman, Adam M.;Shihabuddin, Lina;Hazlett, Erin A.;Buchsbaum, Monte S.
我们之前已经证明，壳核体积而非尾状核体积与慢性精神分裂症患者的不良预后相关。本研究旨在探讨不同结局的慢性精神分裂症患者与健康受试者纹状体体积的进展差异。在基线和四年后的随访中获得结构MRI扫描，以评估26名预后不良的精神分裂症患者，23名预后良好的患者和16名健康受试者的体积变化。不同结果的精神分裂症患者进入研究时，尾状核和壳核的体积相似。结果较差的患者壳核体积下降的速度大于结果较好的患者，因此在随访时，他们的壳核体积明显小于尾状核体积。在精神分裂症患者和健康对照者之间，壳核的基线和随访体积或其进展速度没有差异。在基线和随访中，精神分裂症患者的尾状核体积低于健康受试者，但两组之间没有表现出不同的进展模式。壳核的体积可能代表慢性精神分裂症患者治疗反应性和结果的纵向标记。
We have previously demonstrated that putaminal but not caudate volumes are associated with poor outcome in patients with chronic schizophrenia. Present longitudinal study was designed to investigate progressive differences in striatal volumes among chronic schizophrenia patients with different outcomes and healthy subjects. Structural MRI scans were acquired at baseline and at follow-up four years later to evaluate volumetric changes in 26 poor-outcome schizophrenia patients, 23 good-outcome patients and 16 healthy subjects. Schizophrenia patients with different outcomes entered the study with similar volumes of the caudate nucleus and putamen. The rate of decline in volumes of the putamen was greater in patients with poor outcome than in the good-outcome group, so that their putaminal but not caudate volumes were significantly smaller at the time of follow-up. There were no differences in baseline and follow-up volumes of the putamen or in the rate of their progression among patients with schizophrenia and healthy comparison subjects. The caudate volumes were lower in schizophrenia patients than healthy subjects at baseline and follow-up, but showed no differential patterns of progression between the groups. Volumes of the putamen may represent a longitudinal marker of treatment responsiveness and outcome in patients with chronic schizophrenia.
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