Antioxidative activity and ameliorative effects of memory impairment of sulfur‐containing compounds in Allium species
Antioxidative activity and ameliorative effects of memory impairment of sulfur‐containing compounds in Allium species
复制标题
葱属含硫化合物的抗氧化活性和改善记忆障碍的作用
DOI：
10.1002/biof.5520260204
复制
发表时间：
2006
期刊：
影响因子：
6
通讯作者：
Y. Nomura
中科院分区：
文献类型：
--
作者：
H. Nishimura;Ohki Higuchi;Koutaro Tateshita;K. Tomobe;Y. Okuma;Y. Nomura
研究了洋葱、大蒜等洋葱类蔬菜中含硫化合物的抗氧化活性及其对记忆障碍的改善作用。用人低密度脂蛋白测定了S-烷基(烯)-L-半胱氨酸及其亚硫醚、挥发性烷基(烯)基二硫化物和三硫化物以及乙烯基二硫醚的抗氧化活性。结果表明，化合物中的烷基取代基和硫原子数是影响其抗氧化活性的重要因素。为了证实洋葱提取物和人工合成的二正丙基三硫化物对小鼠记忆障碍的改善作用，对衰老加速的小鼠P8进行了研究。行为学实验表明，洋葱提取物和二正丙基三硫化物对小鼠记忆障碍有明显的改善作用。此外，还发现二正丙基三硫化物可降低衰老加速小鼠P8海马区脂质过氧化氢的含量。这些结果表明，洋葱中含有的二正丙基三硫化物通过其抗氧化作用改善了SAMP8小鼠的记忆障碍。
The antioxidative activity and ameliorative effects on memory impairment by sulfur‐containing compounds which occur in Allium vegetables such as onion and garlic were investigated. The antioxidative activities of S‐alk(en)yl‐L‐cysteines and their sulfoxides, volatile alk(en)yl disulfides and trisulfides, and vinyldithiins were examined by using human low‐density lipoprotein. It was elucidated that the alk(en)yl substituents and the number of sulfur atoms in the compounds were important for the antioxidative activities. To demonstrate the ameliorative effects on memory impairment, onion extract and synthesized di‐n‐propyl trisulfide were administered to senescence‐accelerated mouse P8. The behavioral experiments showed that onion extract and di‐n‐propyl trisulfide had highly ameliorative effect of memory impairment. Furthermore, it was found that the hippocampus lipid hydroperoxide in senescence‐accelerated mouse P8 was decreased by the administration of di‐n‐propyl trisulfide. These results suggest that di‐n‐propyl trisulfide contained in onion ameliorates memory impairment in SAMP8 mouse by its antioxidant effect.
登录
查看更多内容
DOI：
10.1093/geronj/47.2.b52
发表时间：
1992-03-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
FLOOD, JF;MORLEY, JE
通讯作者：
MORLEY, JE
DOI：
10.1073/pnas.88.23.10540
发表时间：
1991-12-01
影响因子：
11.1
作者：
SMITH, CD;CARNEY, JM;MARKESBERY, WR
通讯作者：
MARKESBERY, WR
年轻人和老年人基于模式的检索过程。
DOI：
10.1093/geronj/47.1.p52
发表时间：
1992
期刊：
Journal of gerontology
影响因子：
--
作者：
Hess,TM;Flannagan,DA
通讯作者：
Flannagan,DA
DOI：
10.1073/pnas.93.10.4765
发表时间：
1996-05-14
影响因子：
11.1
作者：
Forster, MJ;Dubey, A;Sohal, RS
通讯作者：
Sohal, RS