Auditory cortex represents both pitch judgments and the corresponding acoustic cues.
Auditory cortex represents both pitch judgments and the corresponding acoustic cues.
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DOI：
10.1016/j.cub.2013.03.003
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发表时间：
2013-04-08
期刊：
影响因子：
9.2
通讯作者：
Schnupp, Jan W. H.
中科院分区：
文献类型：
--
作者：
Bizley, Jennifer K.;Walker, Kerry M. M.;Nodal, Fernando R.;King, Andrew J.;Schnupp, Jan W. H.
感觉刺激的神经加工涉及到将物理刺激参数转换为知觉特征，而阐明这种转换发生在哪里以及如何发生是感觉神经生理学的最终目标之一。最近的研究表明，早期感觉皮质神经元的放电可以受到多感觉相互作用、运动行为和奖励反馈的调节，但尚不清楚神经活动与感知(如行为选择所示)更密切相关，还是与刺激的物理属性更密切相关。我们通过记录雪貂的局域场电位(LFP)和多单位放电活动，同时辨别人工元音的音高，研究了这些特性中哪些在听觉皮质中主要表现出来。我们发现，听觉皮质活动既是关于目标声音的基频(F0)的信息，也是关于动物在给定行为反应时似乎感知到的音调的信息。令人惊讶的是，尽管刺激F0在目标声音开始时被很好地呈现，但整个听觉皮质的神经活动经常比目标F0更好地预测报告的音调。►听觉皮层反应被记录下来，而雪貂辨别音调变化时，►LFP和多单位活动对声音的基频(F0)敏感。在整个试验过程中，与动物报告的音调增加相关的►神经活动►皮层反应比声音F0更能提供有关行为选择的信息
The neural processing of sensory stimuli involves a transformation of physical stimulus parameters into perceptual features, and elucidating where and how this transformation occurs is one of the ultimate aims of sensory neurophysiology. Recent studies have shown that the firing of neurons in early sensory cortex can be modulated by multisensory interactions, motor behavior, and reward feedback, but it remains unclear whether neural activity is more closely tied to perception, as indicated by behavioral choice, or to the physical properties of the stimulus. We investigated which of these properties are predominantly represented in auditory cortex by recording local field potentials (LFPs) and multiunit spiking activity in ferrets while they discriminated the pitch of artificial vowels. We found that auditory cortical activity is informative both about the fundamental frequency (F0) of a target sound and also about the pitch that the animals appear to perceive given their behavioral responses. Surprisingly, although the stimulus F0 was well represented at the onset of the target sound, neural activity throughout auditory cortex frequently predicted the reported pitch better than the target F0. ► Auditory cortical responses were recorded while ferrets discriminated pitch shifts ► LFP and multiunit activity are sensitive to the sound’s fundamental frequency (F0) ► Neural activity related to animals’ reported pitch increases throughout the trial ► Cortical responses were more informative about behavioral choices than the sound F0
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DOI：
10.1523/jneurosci.5475-09.2010
发表时间：
2010-04-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bizley JK;Walker KM;King AJ;Schnupp JW
通讯作者：
Schnupp JW
影响因子：
25
作者：
Jaramillo, Santiago;Zador, Anthony M.
通讯作者：
Zador, Anthony M.
影响因子：
1.2
作者：
Belitski, Andrei;Panzeri, Stefano;Magri, Cesare;Logothetis, Nikos K.;Kayser, Christoph
通讯作者：
Kayser, Christoph
DOI：
10.1093/cercor/bhl128
发表时间：
2007-09
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Bizley JK;Nodal FR;Bajo VM;Nelken I;King AJ
通讯作者：
King AJ
影响因子：
2.5
作者：
Campbell RA;Schulz AL;King AJ;Schnupp JW
通讯作者：
Schnupp JW