Antimicrobial Properties of MgO Nanostructures on Magnesium Substrates.
Antimicrobial Properties of MgO Nanostructures on Magnesium Substrates.
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DOI：
10.1021/acsomega.0c03151
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发表时间：
2020-09-29
期刊：
影响因子：
4.1
通讯作者：
Liu HH
中科院分区：
文献类型：
--
作者：
Lin J;Nguyen NT;Zhang C;Ha A;Liu HH
镁及其合金具有良好的力学和生物性能，近年来作为修复肌肉骨骼损伤的医用植入物受到越来越多的关注。然而，镁及其合金在生理液体中的快速降解限制了它们的临床转化，因为氢(H2)气体的积累和OH-离子的快速释放可能会对愈合过程产生不利影响。此外，感染是内部植入装置的主要问题，因为它可能导致生物膜的形成，阻止宿主细胞附着在种植体上，并干扰骨整合，导致种植失败或其他并发症。在镁(Mg)衬底上制备纳米氧化镁(MgO)有望解决这两个问题，因为它可以减缓降解过程，提高抗菌活性。在本研究中，利用两种不同的表面处理技术，即阳极氧化和电泳沉积(EPD)，在镁衬底上形成了纳米结构的氧化镁薄膜，并在体外与金黄色葡萄球菌共同培养，以确定其抗菌性能。在细菌培养结束时，阳极氧化法和电沉积法制备的镁表面纳米氧化镁薄膜对金黄色葡萄球菌均有明显的杀菌效果。因此，镁表面的纳米结构氧化镁涂层在减少种植体相关感染和并发症方面很有希望，应该进一步探索临床向抗菌可生物降解种植体的转化。
Magnesium (Mg) and its alloys have attracted increasing attention in recent years as medical implants for repairing musculoskeletal injuries because of their promising mechanical and biological properties. However, rapid degradation of Mg and its alloys in physiological fluids limited their clinical translation because the accumulation of hydrogen (H2) gas and fast release of OH– ions could adversely affect the healing process. Moreover, infection is a major concern for internally implanted devices because it could lead to biofilm formation, prevent host cell attachment on the implants, and interfere osseointegration, resulting in implant failure or other complications. Fabricating nanostructured magnesium oxide (MgO) on magnesium (Mg) substrates is promising in addressing both problems because it could slow down the degradation process and improve the antimicrobial activity. In this study, nanostructured MgO layers were created on Mg substrates using two different surface treatment techniques, i.e., anodization and electrophoretic deposition (EPD), and cultured with Staphylococcus aureus in vitro to determine their antimicrobial properties. At the end of the 24-h bacterial culture, the nanostructured MgO layers on Mg prepared by anodization or EPD both showed significant bactericidal effect against S. aureus. Thus, nanostructured MgO layers on Mg are promising for reducing implant-related infections and complications and should be further explored for clinical translation toward antimicrobial biodegradable implants.
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