Pathogenic Mechanisms and Host Interactions in Staphylococcus epidermidis Device-Related Infection.
Pathogenic Mechanisms and Host Interactions in Staphylococcus epidermidis Device-Related Infection.
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DOI：
10.3389/fmicb.2017.01401
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发表时间：
2017
影响因子：
5.2
通讯作者：
Moriarty TF
中科院分区：
文献类型：
--
作者：
Sabaté Brescó M;Harris LG;Thompson K;Stanic B;Morgenstern M;O'Mahony L;Richards RG;Moriarty TF
表皮葡萄球菌是正常人类微生物群的永久成员，常见于皮肤和粘膜上。通过特定的粘附素粘附到宿主的组织表面部分，表皮葡萄球菌能够从生命早期就开始与人类建立终生的共生关系。作为一种共生生物，表皮葡萄球菌被认为可以为人类宿主带来好处，包括在竞争中击败毒性更强的病原体。然而，很大程度上由于其能够在植入的异物上形成生物膜，表皮葡萄球菌已成为接受医疗器械的患者中的重要机会病原体。表皮葡萄球菌约占所有骨科器械相关感染 (ODRI) 的 20%，在晚期感染中这一比例增加至 50%。尽管如此普遍，但它在科学文献中的代表性仍然不足，特别是落后于金黄色葡萄球菌的研究。本综述旨在概述表皮葡萄球菌作为共生体和病原体与人类宿主的相互作用。将描述表皮葡萄球菌保留的能够在人类皮肤定植以及侵入性感染的机制，特别关注生物膜的形成。还描述了宿主对这些感染的免疫反应，包括表皮葡萄球菌似乎如何触发低水平的促炎细胞因子和高水平的白细胞介素-10，这可能导致通常与这些感染相关的亚急性和持续性性质。对表皮葡萄球菌的适应性免疫反应的描述仍然很少，并且代表了一个可能在未来几年提供重要新发现的领域。
Staphylococcus epidermidis is a permanent member of the normal human microbiota, commonly found on skin and mucous membranes. By adhering to tissue surface moieties of the host via specific adhesins, S. epidermidis is capable of establishing a lifelong commensal relationship with humans that begins early in life. In its role as a commensal organism, S. epidermidis is thought to provide benefits to human host, including out-competing more virulent pathogens. However, largely due to its capacity to form biofilm on implanted foreign bodies, S. epidermidis has emerged as an important opportunistic pathogen in patients receiving medical devices. S. epidermidis causes approximately 20% of all orthopedic device-related infections (ODRIs), increasing up to 50% in late-developing infections. Despite this prevalence, it remains underrepresented in the scientific literature, in particular lagging behind the study of the S. aureus. This review aims to provide an overview of the interactions of S. epidermidis with the human host, both as a commensal and as a pathogen. The mechanisms retained by S. epidermidis that enable colonization of human skin as well as invasive infection, will be described, with a particular focus upon biofilm formation. The host immune responses to these infections are also described, including how S. epidermidis seems to trigger low levels of pro-inflammatory cytokines and high levels of interleukin-10, which may contribute to the sub-acute and persistent nature often associated with these infections. The adaptive immune response to S. epidermidis remains poorly described, and represents an area which may provide significant new discoveries in the coming years.
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影响因子：
2.7
作者：
Brancatisano, Franca Lisa;Maisetta, Giuseppantonio;Batoni, Giovanna
通讯作者：
Batoni, Giovanna
DOI：
10.1302/0301-620x.79b5.7228
发表时间：
1997-09-01
影响因子：
--
作者：
An, YH;Bradley, J;Friedman, RJ
通讯作者：
Friedman, RJ
影响因子：
3.1
作者：
Ahmed, S;Meghji, S;Nair, SP
通讯作者：
Nair, SP
影响因子：
3.2
作者：
Bennallack, Philip R.;Burt, Scott R.;Griffitts, Joel S.
通讯作者：
Griffitts, Joel S.
DOI：
10.1007/s10096-010-0966-3
发表时间：
2010-09-01
影响因子：
4.5
作者：
Bjorkqvist, M.;Liljedahl, M.;Soderquist, B.
通讯作者：
Soderquist, B.