Opioid use as a potential risk factor for pancreatic cancer in the United States: An analysis of state and national level databases.
Opioid use as a potential risk factor for pancreatic cancer in the United States: An analysis of state and national level databases.
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DOI：
10.1371/journal.pone.0244285
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Bishehsari F
中科院分区：
文献类型：
--
作者：
Barlass U;Deshmukh A;Beck T;Bishehsari F
近年来，处方和非法阿片类药物的使用也在全国范围内持续上升。阿片类药物已被证明对多种类型的癌症有有害影响，最近的数据表明鸦片使用是PC的一个危险因素。使用国家数据库，我们测试了阿片类药物使用模式随时间的变化是否可以解释美国州和国家基于PC率的变化。阿片类药物死亡率（作为处方和非法阿片类药物使用的替代品）是通过生命统计合作计划从cdc Wonder在线数据中提取的。胰腺癌的发病率是从美国癌症统计工作组收集的在线cdc数据库中检索的。从行为危险因素监测系统中收集肥胖、吸烟和饮酒的流行情况。使用混合效应回归模型检验1999-2016年期间PC率水平与阿片类药物死亡/使用率之间的关系。随着时间的推移，在国家和州的层面上，个人所得税都有所上升。同样，阿片类药物的死亡率也随着时间的推移而增加。在其他潜在的PC危险因素中，只有肥胖患病率在研究期间有所增加。一个州4年前的阿片类药物死亡率显著预测了PC的初始发病率（β = 0.1848, p<0.0001），并对PC发病率的估计年变化有显著影响（β = - 0.0193,p<0.0001）。阿片类药物的使用可能是导致美国PC发病率增加的一个未确定的危险因素。这些新发现需要通过基于人群的研究来验证。
Pancreatic cancer (PC) rate is increasing in the U.S. The use of prescription and illicit opioids has continued to rise nationally in recent years as well. Opioids have been shown to have a deleterious effect on multiple types of cancer with recent data suggesting opium use as a risk factor for PC. Using national databases, we tested whether opioid usage pattern over time could explain the state and national-based variations in PC rates in the U.S. Opioid death rate (as a surrogate for prescription and illicit opioid use) was extracted from the CDCs Wonder online data through the Vital Statistics Cooperative Program. Incidence of pancreatic cancer was retrieved from the online CDCs data base gathered from the U.S. Cancer Statistics Working Group. Prevalence of obesity, tobacco and alcohol use was collected from Behavioral risk factor surveillance system. Mixed-effects regression models were used to test the association between levels of PC rate and opioid death/use rates during the years 1999–2016. A rise in PC was seen over time at the national and state levels. Similarly, the opioid death rates increased over time. Among other potential PC risk factors, only obesity prevalence showed an increase during the study period. A state’s opioid death rate at 4 years prior significantly predicted initial incidence of PC (β = 0.1848, p<0.0001) and had a significant effect on the estimated annual change in the rate of PC (β = -.0193,p<0.0001). Opioid use may be an un-identified risk factor contributing to the increasing incidence of PC in the U.S. These novel findings need to be verified by population-based studies.
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影响因子：
1.6
作者：
Shakeri, Ramin;Kamangar, Farin;Pourshams, Akram
通讯作者：
Pourshams, Akram
影响因子：
13.8
作者：
Wu, Bechien U.;Butler, Rebecca K.;Chen, Wansu
通讯作者：
Chen, Wansu
DOI：
10.1016/j.bpg.2017.09.001
发表时间：
2017-10
期刊：
Best practice & research. Clinical gastroenterology
影响因子：
--
作者：
Korc M;Jeon CY;Edderkaoui M;Pandol SJ;Petrov MS;Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
通讯作者：
Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
影响因子：
2.9
作者：
Chari ST;Kelly K;Hollingsworth MA;Thayer SP;Ahlquist DA;Andersen DK;Batra SK;Brentnall TA;Canto M;Cleeter DF;Firpo MA;Gambhir SS;Go VL;Hines OJ;Kenner BJ;Klimstra DS;Lerch MM;Levy MJ;Maitra A;Mulvihill SJ;Petersen GM;Rhim AD;Simeone DM;Srivastava S;Tanaka M;Vinik AI;Wong D
通讯作者：
Wong D
影响因子：
1.9
作者：
LAIRD, NM;WARE, JH
通讯作者：
WARE, JH