MicroRNAs: miRRORS of health and disease.
MicroRNAs: miRRORS of health and disease.
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DOI：
10.1016/j.trsl.2011.02.001
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Montano M
中科院分区：
文献类型：
--
作者：
Montano M
这期的综述文章提供了对miRNA作为组织发育过程中谱系承诺和调控指导的基本特征的更好认识，当缺乏或受阻时，往往导致疾病状态。在未来的几年里，通过研究miRNA的表达如何受到miR基因、簇和镜像的遗传结构的影响，以及miRNA多态性及其mRNA靶点的多态性，有很多关于适应（和不适应）状态的知识需要学习。我们还介绍了miRNA调节的几种模式（负反馈、正反馈、交叉调节），这些模式监测、调节或解决各种生物过程中的信号通路，包括败血症反应、纤维化、急性运动和类固醇生物学。也许这些miRNA调节系统的内稳态或微管理，当受到干扰时，会达到新的稳定的网络相互作用，这些相互作用具有促进或对抗疾病严重程度和癌症进展的意想不到的效果。显然，更好地理解这些miRNA调控网络，以及改进的治疗工具来指导miRNA表达及其目标，将是未来几年miRNA生物学的许多进展的主题。
The review articles in this issue provide an improved appreciation for miRNA as an essential feature of lineage commitment and regulatory guidance during tissue development, that when absent or hampered, often lead to disease states. In the coming years, there is much to be learned about adaptive (and maladaptive) states by examining how expression of miRNAs is influenced by the genetic architecture of miR genes, clusters and mirtrons, as well as miRNA polymorphism and polymorphism in their mRNA targets. We were also introduced to several modes of miRNA regulation (negative feedback, positive feedback, cross-regulatory) that monitor, modulate or resolve signaling pathways in a variety of biological processes that include sepsis response, fibrosis, acute exercise and steroid biology. Perhaps the homeostasis or micromanagement of these miRNA regulatory systems, when perturbed arrive at new stable networked interactions that have an undesired effect of promoting or antagonizing disease severity and cancer progression. Clearly, a better understanding of these miRNA regulatory networks, as well as improved therapeutic tools for guiding miRNA expression and their targets towards desired outcomes will be the subject of many advances in miRNA biology over the coming years.
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DOI：
10.1016/j.trsl.2011.01.010
发表时间：
2011-04
期刊：
Translational research : the journal of laboratory and clinical medicine
影响因子：
--
作者：
Zhou T;Garcia JG;Zhang W
通讯作者：
Zhang W
DOI：
10.1016/j.trsl.2011.01.008
发表时间：
2011-04
期刊：
Translational research : the journal of laboratory and clinical medicine
影响因子：
--
作者：
Kerr TA;Korenblat KM;Davidson NO
通讯作者：
Davidson NO
影响因子：
16.6
作者：
Nishikura K
通讯作者：
Nishikura K
DOI：
10.1016/j.trsl.2010.12.013
发表时间：
2011-04
期刊：
Translational research : the journal of laboratory and clinical medicine
影响因子：
--
作者：
Dorn GW 2nd
通讯作者：
Dorn GW 2nd
影响因子：
30.8
作者：
Clop, Alex;Marcq, Fabienne;Georges, Michel
通讯作者：
Georges, Michel