Antibacterial and anti-biofilm activities of thiazolidione derivatives against clinical staphylococcus strains.
Antibacterial and anti-biofilm activities of thiazolidione derivatives against clinical staphylococcus strains.
复制标题
噻唑烷酮衍生物对临床葡萄球菌菌株的抗菌和抗生物膜活性
DOI：
10.1038/emi.2015.1
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发表时间：
2015-01
影响因子：
13.2
通讯作者：
Qu, Di
中科院分区：
文献类型：
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作者：
Liu, Huayong;Zhao, Yanfeng;Zhao, Dan;Gong, Ting;Wu, Youcong;Han, Haiyan;Xu, Tao;Peschel, Andreas;Han, Shiqing;Qu, Di
关键词：
金黄色葡萄球菌和表皮葡萄球菌均可在天然表面或非生物表面（如医用植入物）上形成生物膜，导致抗生素治疗无效的生物膜相关疾病。我们以前报道了一种有前途的抗菌化合物（化合物2）及其衍生物，具有杀菌和抗生物膜活性对这两个。表皮病和S.金黄色。我们进一步评价了四个化合物2衍生物（H2-38、H2-39、H2-74和H2-81）对163株临床分离的沙门氏菌的抗菌活性。表皮病和S.金黄色葡萄球菌，包括甲氧西林敏感和耐甲氧西林菌株，以及生物膜形成和非生物膜形成菌株。这四种衍生物抑制了所有临床葡萄球菌分离株的生长，包括耐甲氧西林葡萄球菌。金黄色葡萄球菌和耐甲氧西林表皮葡萄球菌对由强生物膜形成菌株形成的未成熟（6h）和成熟（24 h）生物膜均显示杀菌活性。 这些衍生物都靶向YycG，将有助于我们开发新的抗多药耐药葡萄球菌感染和生物膜相关疾病的抗菌药物。
BothStaphylococcus aureusandStaphylococcus epidermidiscan form biofilms on natural surfaces or abiotic surfaces, such as medical implants, resulting in biofilm-associated diseases that are refractory to antibiotic treatment. We previously reported a promising antibacterial compound (Compound 2) and its derivatives with bactericidal and anti-biofilm activities against bothS. epidermidisandS. aureus. We have further evaluated the antibacterial activities of four Compound 2 derivatives (H2-38, H2-39, H2-74 and H2-81) against 163 clinical strains ofS. epidermidisandS. aureus, including methicillin-susceptible and methicillin-resistant strains, as well as biofilm-forming and non-biofilm-forming strains. The four derivatives inhibited the planktonic growth of all of the clinical staphylococcal isolates, including methicillin-resistantS. aureusand methicillin-resistant S.epidermidisand displayed bactericidal activities against both immature (6 h) and mature (24 h) biofilms formed by the strong biofilm-forming strains. The derivatives, which all target YycG, will help us to develop new antimicrobial agents against multidrug-resistant staphylococci infections and biofilm-associated diseases.
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影响因子：
56.9
作者：
HALSTEAD, SB
通讯作者：
HALSTEAD, SB
影响因子：
168.9
作者：
Guzman, Maria G.;Harris, Eva
通讯作者：
Harris, Eva
影响因子：
64.8
作者：
Walker, T.;Johnson, P. H.;Hoffmann, A. A.
通讯作者：
Hoffmann, A. A.
影响因子：
17.1
作者：
Marston, Hilary D.;Folkers, Gregory K.;Fauci, Anthony S.
通讯作者：
Fauci, Anthony S.
影响因子：
64.8
作者：
通讯作者：
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