The circadian clock in skin: implications for adult stem cells, tissue regeneration, cancer, aging, and immunity.
The circadian clock in skin: implications for adult stem cells, tissue regeneration, cancer, aging, and immunity.
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DOI：
10.1177/0748730414563537
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发表时间：
2015-06
影响因子：
3.5
通讯作者：
Andersen B
中科院分区：
文献类型：
--
作者：
Plikus MV;Van Spyk EN;Pham K;Geyfman M;Kumar V;Takahashi JS;Andersen B
从历史上看，外周生物钟的研究一直集中在具有突出代谢功能的器官和组织上，如肝脏、脂肪和肌肉。近年来，皮肤逐渐成为研究细胞增殖、干细胞功能、组织再生、衰老和癌变的生物钟调节的模型。从形态学上讲，皮肤是复杂的，包含多种细胞类型和结构，并且有证据表明，在大多数（如果不是全部）细胞类型中存在功能性昼夜节律钟。尽管复杂，皮肤干细胞群体是明确定义的，实验上易于处理，并表现出突出的每日细胞增殖周期。毛囊干细胞也参与了周期性的、持久的再生周期--毛发生长周期。皮肤的其他优点之一是广泛的可用遗传工具库，使得能够产生细胞类型特异性昼夜节律突变体。此外，由于皮肤的可接近性，体内成像技术可以很容易地应用于真实的时间研究生物钟及其输出，甚至在单细胞水平。皮肤提供了抵御许多环境和压力因素的第一道防线，这些因素表现出戏剧性的昼夜变化，如太阳紫外线辐射和温度。研究已经将生物钟与UVB诱导的DNA损伤和皮肤癌的控制联系起来。由于皮肤在抵御微生物方面发挥着重要作用，它代表了一个有前途的模型系统，以进一步探索生物钟在调节人体免疫功能中的作用。为此，最近的研究已经将生物钟与牛皮癣联系起来，牛皮癣是最常见的免疫介导的皮肤病之一。皮肤还提供了在干细胞和再生的背景下询问组织代谢的时钟调节的机会。此外，许多动物物种具有显著的季节性脱毛周期，为研究生物钟在季节性生物行为中的作用提供了一个有吸引力的模型。
Historically work on peripheral circadian clocks has been focused on organs and tissues that have prominent metabolic functions, such as liver, fat and muscle. In recent years, skin is emerging as a model for studying circadian clock regulation of cell proliferation, stem cell functions, tissue regeneration, aging and carcinogenesis. Morphologically skin is complex, containing multiple cell types and structures, and there is evidence for a functional circadian clock in most, if not all, of its cell types. Despite the complexity, skin stem cell populations are well defined, experimentally tractable and exhibit prominent daily cell proliferation cycles. Hair follicle stem cells also participate in recurrent, long-lasting cycles of regeneration -- the hair growth cycles. Among other advantages of skin is a broad repertoire of available genetic tools enabling the creation of cell-type specific circadian mutants. Also, due to the accessibility of the skin, in vivo imaging techniques can be readily applied to study the circadian clock and its outputs in real time, even at the single-cell level. Skin provides the first line of defense against many environmental and stress factors that exhibit dramatic diurnal variations such as solar UV radiation and temperature. Studies have already linked the circadian clock to the control of UVB-induced DNA damage and skin cancers. Due to the important role that skin plays in the defense against microorganisms, it represents a promising model system to further explore the role of the clock in the regulation of the body's immune functions. To that end, recent studies have already linked the circadian clock to psoriasis, one of the most common immune-mediated skin disorders. The skin also provides opportunities to interrogate clock regulation of tissue metabolism in the context of stem cells and regeneration. Furthermore, many animal species feature prominent seasonal hair molt cycles, offering an attractive model for investigating the role of clock in seasonal organismal behaviors.
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影响因子：
64.5
作者：
Balsalobre, A;Damiola, F;Schibler, U
通讯作者：
Schibler, U
影响因子：
18.2
作者：
Campisi J
通讯作者：
Campisi J
DOI：
10.1111/j.1365-2184.1979.tb00154.x
发表时间：
1979-01-01
期刊：
CELL AND TISSUE KINETICS
影响因子：
--
作者：
CLAUSEN, OPF;THORUD, E;ELGJO, K
通讯作者：
ELGJO, K
DOI：
10.1073/pnas.1003878107
发表时间：
2010-08-31
影响因子：
11.1
作者：
Akashi, Makoto;Soma, Haruhiko;Node, Koichi
通讯作者：
Node, Koichi
影响因子：
4.6
作者：
Abe, Takaya;Sakaue-Sawano, Asako;Fujimori, Toshihiko
通讯作者：
Fujimori, Toshihiko