Review of hair follicle dermal cells.
Review of hair follicle dermal cells.
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DOI：
10.1016/j.jdermsci.2009.11.005
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发表时间：
2010-01
影响因子：
4.6
通讯作者：
Cotsarelis G
中科院分区：
文献类型：
--
作者：
Yang CC;Cotsarelis G
上皮隆突中的毛囊干细胞负责毛囊在循环过程中的持续再生。隆突细胞位于真皮细胞组成的小生境中。毛囊的真皮区室由真皮乳头和真皮鞘组成。毛囊上皮细胞和真皮细胞之间的相互作用是毛囊发育和毛发重建过程中形态发生所必需的。毛乳头和真皮鞘细胞表达特异性标记，在培养中具有独特的形态和行为。这些细胞可以诱导上皮细胞中的毛囊分化，并且以完整组织、解离的新鲜制备的细胞或培养的细胞的形式在毛发重建测定中是必需的。这篇综述将集中在毛囊真皮细胞，因为迄今为止大多数治疗工作都集中在毛囊的这方面，其想法是丰富毛发诱导真皮细胞群并通过培养扩大其数量，同时保持其特性，将建立一种有效的毛发重建测定法，最终可能具有治疗意义。
Hair follicle stem cells in the epithelial bulge are responsible for the continual regeneration of the hair follicle during cycling. The bulge cells reside in a niche composed of dermal cells. The dermal compartment of the hair follicle consists of the dermal papilla and dermal sheath. Interactions between hair follicle epithelial and dermal cells are necessary for hair follicle morphogenesis during development and in hair reconstitution assays. Dermal papilla and dermal sheath cells express specific markers and possess distinctive morphology and behavior in culture. These cells can induce hair follicle differentiation in epithelial cells and are required in hair reconstitution assays either in the form of intact tissue, dissociated freshly-prepared cells or cultured cells. This review will focus on hair follicle dermal cells since most therapeutic efforts to date have concentrated on this aspect of the hair follicle, with the idea that enriching hair-inductive dermal cell populations and expanding their number by culture while maintaining their properties, will establish an efficient hair reconstitution assay that could eventually have therapeutic implications.
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