Development of a colorimetric and NIR fluorescent dual probe for carbon monoxide
Development of a colorimetric and NIR fluorescent dual probe for carbon monoxide
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开发一氧化碳比色和近红外荧光双探针
DOI：
10.1039/c6ra14409h
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发表时间：
2016-07
期刊：
影响因子：
3.9
通讯作者：
Zhang Lei
中科院分区：
文献类型：
--
作者：
Yan Jin-wu;Zhu Jia-ying;Tan Qi-feng;Zhou Lin-fu;Yao Pei-fen;Lu Yu-ting;Tan Jia-heng;Zhang Lei
一氧化碳（CO）引起了极大的关注，部分原因是发现了CO在生物系统中发挥的治疗和细胞信号作用。对CO的兴趣不断增加，导致开发了用于灵敏和选择性检测CO的快速和简便的方法，这仍然具有挑战性。在此，一氧化碳（CO）的比色和近红外荧光双探针的第一个例子已经开发通过组装烯丙基氯甲酸酯部分与naphthofluorescein荧光团，这使得无标记和视觉检测的CO。活细胞成像结果表明，该探针在传感细胞内CO显示出巨大的潜力。
Carbon monoxide (CO) has captivated great attention in part due to the discovery of the therapeutic and cell-signalling role that CO plays in biological systems. The ever-increasing interest in CO has resulted in the development of rapid and facile approaches for the sensitive and selective detection of CO, which still remains challenging. Herein, the first example of a colorimetric and near-infrared fluorescent dual probe for carbon monoxide (CO) has been developed by assembling an allyl chloroformate moiety with a naphthofluorescein fluorophore, which enables the label-free and visual detection of CO. The living cell imaging results indicate that the probe shows great potential in sensing intracellular CO.
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