Super-Resolution Arterial Spin Labeling Using Slice-Dithered Enhanced Resolution and Simultaneous Multi-Slice Acquisition.
Super-Resolution Arterial Spin Labeling Using Slice-Dithered Enhanced Resolution and Simultaneous Multi-Slice Acquisition.
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DOI：
10.3389/fnins.2021.737525
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发表时间：
2021
影响因子：
4.3
通讯作者：
Wang DJJ
中科院分区：
文献类型：
--
作者：
Shou Q;Shao X;Wang DJJ
目的：使用二维同步多切片（SMS）伪连续动脉自旋标记（pCASL）和切片抖动增强分辨率（SLIDER）技术进行超分辨率重建，实现高空间分辨率（各向同性-2 mm）灌注成像。研究方法：SLIDER-SMS pCASL的多波段因子为4，在3 T下执行，切片厚度分别为4/6/8 mm，切片移位次数为3次（2/3/4）。采用奇异值分解和不同层次的Tikhonov正则化进行超分辨率重建。在5名健康受试者中测量超分辨率ASL图像的时间和空间信噪比（SNR）以及空间模糊效应，并与参考高分辨率ASL图像进行比较。结果如下：与传统的2D SMS ASL相比，各向同性2 mm分辨率的超分辨率ASL图像的空间SNR分别高出42%、61%和88%，时间SNR分别高出18%、55%和105%，切片移位数为2/3/4。SLIDER重建的空间模糊效应从两个切片移位增加到四个切片移位。结论：与标准2D SMS pCASL相比，所提出的SLIDER-SMS pCASL技术可以实现全脑高分辨率灌注图像，扫描时间为15分钟，SNR提高。量化和控制SLIDER重建的模糊效果需要谨慎。
Purpose: To achieve high spatial resolution (isotropic-2 mm) perfusion imaging using 2D simultaneous multi-slice (SMS) pseudo-continuous arterial spin labeling (pCASL) and slice dithered enhanced resolution (SLIDER) technique for super-resolution reconstruction. Methods: The SLIDER-SMS pCASL with a multiband factor of 4 was implemented at 3T with three numbers of slice shift (2/3/4) for the slice thickness of 4/6/8 mm, respectively. Super-resolution reconstruction was performed with singular value decomposition and different levels of Tikhonov regularizations. Temporal and spatial signal-to-noise ratio (SNR) as well as spatial blurring effects of super-resolution ASL images were measured in five healthy subjects and compared with those of reference high-resolution ASL images. Results: Compared to conventional 2D SMS ASL, super-resolution ASL images with isotropic-2-mm resolution yielded 42, 61, and 88% higher spatial SNR, and 18, 55, and 105% higher temporal SNR with slice shift number of 2/3/4, respectively. Spatial blurring effect increased for SLIDER reconstruction from two to four slice shifts. Conclusion: The proposed SLIDER-SMS pCASL technique can achieve whole-brain high-resolution perfusion images with ∼15-min scan time and improved SNR compared to standard 2D SMS pCASL. Caution needs to be exercised on quantifying and controlling blurring effects of SLIDER reconstruction.
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影响因子：
2.5
作者：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
5.7
作者：
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通讯作者：
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