Sex hormone-binding globulin and risk of clinical diabetes in American black, Hispanic, and Asian/Pacific Islander postmenopausal women.
Sex hormone-binding globulin and risk of clinical diabetes in American black, Hispanic, and Asian/Pacific Islander postmenopausal women.
复制标题
DOI：
10.1373/clinchem.2012.193086
复制
发表时间：
2012-10
影响因子：
9.3
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Chen BH;Brennan K;Goto A;Song Y;Aziz N;You NC;Wellons MF;Manson JE;White DL;Butch AW;Liu S
最近的前瞻性研究表明，在白色个体中，性激素结合球蛋白（SHBG）浓度与临床糖尿病风险之间存在强烈的负相关性。然而，目前尚不清楚这种关系是否延伸到其他种族/族裔人口。我们在妇女健康倡议观察性研究中评估了SHBG基线浓度与临床糖尿病风险之间的关系。在平均5.9年的随访中，我们确定了642名绝经后妇女发生临床糖尿病（380名黑人，157名西班牙裔，105名亚洲人）和1286名匹配的对照（777名黑人，307名西班牙裔，202名亚洲人）。基线时较高的SHBG浓度与临床糖尿病风险显著降低相关[SHBG最高与最低四分位数的相对风险（RR），0.15; 95%CI，0.09-0.26，经BMI和已知糖尿病风险因素校正]。种族组内的相关性保持一致[黑人RR，0.19（95%CI，0.10-0.38）;西班牙裔RR，0.17（95%CI，0.05-0.57）;亚洲人RR，0.13（95%CI，0.03-0.48）]。调整潜在混杂因素，如总睾酮（RR，0.11; 95% CI，0.07-0.19）或HOMA-IR（RR，0.26; 95% CI，0.14-0.48），RR没有显著改变。此外，SHBG浓度与临床糖尿病的风险显著相关，（从未使用者：RR/SD = 0.42，95% CI，0.34-0.51;既往使用者：RR/SD = 0.53; 95% CI，0.37-0.77;当前使用者：RR/SD = 0.57; 95% CI，0.46-0.69; P-相互作用= 0.10）。在这项绝经后妇女的前瞻性研究中，我们观察到美国黑人、西班牙裔和亚洲人/太平洋岛民血清SHBG浓度与临床糖尿病风险之间存在稳健的负相关关系。这些关联似乎与性激素浓度、肥胖或胰岛素抵抗无关。
Recent prospective studies have shown a strong inverse association between sex hormone–binding globulin (SHBG) concentrations and risk of clinical diabetes in white individuals. However, it remains unclear whether this relationship extends to other racial/ethnic populations. We evaluated the association between baseline concentrations of SHBG and clinical diabetes risk in the Women’s Health Initiative Observational Study. Over a median follow-up of 5.9 years, we identified 642 postmenopausal women who developed clinical diabetes (380 blacks, 157 Hispanics, 105 Asians) and 1286 matched controls (777 blacks, 307 Hispanics, 202 Asians). Higher concentrations of SHBG at baseline were associated with a significantly lower risk of clinical diabetes [relative risk (RR), 0.15; 95% CI, 0.09–0.26 for highest vs lowest quartile of SHBG, adjusted for BMI and known diabetes risk factors]. The associations remained consistent within ethnic groups [RR, 0.19 (95% CI, 0.10–0.38) for blacks; RR, 0.17 (95% CI, 0.05–0.57) for Hispanics; and 0.13 (95% CI, 0.03–0.48) for Asians]. Adjustment for potential confounders, such as total testosterone (RR, 0.11; 95% CI, 0.07–0.19) or HOMA-IR (RR, 0.26; 95% CI, 0.14–0.48) did not alter the RR substantially. In addition, SHBG concentrations were significantly associated with risk of clinical diabetes across categories of hormone therapy use (never users: RRper SD = 0.42, 95% CI, 0.34–0.51; past users: RRper SD = 0.53;, 95% CI, 0.37–0.77; current users: RRper SD = 0.57; 95% CI, 0.46–0.69; P-interaction = 0.10). In this prospective study of postmenopausal women, we observed a robust, inverse relationship between serum concentrations of SHBG and risk of clinical diabetes in American blacks, Hispanics, and Asians/Pacific Islanders. These associations appeared to be independent of sex hormone concentrations, adiposity, or insulin resistance.
登录
查看更多内容
影响因子：
5.8
作者：
Miller, KK;Rosner, W;Klibanski, A
通讯作者：
Klibanski, A
影响因子：
3.5
作者：
Perry JR;Weedon MN;Langenberg C;Jackson AU;Lyssenko V;Sparsø T;Thorleifsson G;Grallert H;Ferrucci L;Maggio M;Paolisso G;Walker M;Palmer CN;Payne F;Young E;Herder C;Narisu N;Morken MA;Bonnycastle LL;Owen KR;Shields B;Knight B;Bennett A;Groves CJ;Ruokonen A;Jarvelin MR;Pearson E;Pascoe L;Ferrannini E;Bornstein SR;Stringham HM;Scott LJ;Kuusisto J;Nilsson P;Neptin M;Gjesing AP;Pisinger C;Lauritzen T;Sandbaek A;Sampson M;MAGIC;Zeggini E;Lindgren CM;Steinthorsdottir V;Thorsteinsdottir U;Hansen T;Schwarz P;Illig T;Laakso M;Stefansson K;Morris AD;Groop L;Pedersen O;Boehnke M;Barroso I;Wareham NJ;Hattersley AT;McCarthy MI;Frayling TM
通讯作者：
Frayling TM
影响因子：
--
作者：
Liu, Simin;Tinker, Lesley;Manson, JoAnn E.
通讯作者：
Manson, JoAnn E.
影响因子：
5.6
作者：
Anderson, GL;Manson, J;Prentice, RL
通讯作者：
Prentice, RL
影响因子：
--
作者：
Hammond, GL;Bocchinfuso, WP
通讯作者：
Bocchinfuso, WP