Nanoparticle-based local antimicrobial drug delivery.
Nanoparticle-based local antimicrobial drug delivery.
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DOI：
10.1016/j.addr.2017.09.015
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发表时间：
2018-03-01
影响因子：
16.1
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Gao W;Chen Y;Zhang Y;Zhang Q;Zhang L
尽管抗生素在现代医学中取得了广泛的成功，但细菌感染的治疗仍然面临着严峻的挑战，特别是由于抗生素耐药性的迅速出现。因此，旨在提高感染部位药物浓度同时避免全身暴露的局部抗菌治疗正变得越来越有吸引力，因为它可以减轻耐药性的发展。同时，治疗性纳米颗粒，特别是脂质体、聚合纳米颗粒、树突状分子和无机纳米颗粒，在局部抗菌治疗方面的应用越来越广泛，从而提高了治疗效果。这篇综述强调了基于纳米颗粒的策略在推进局部细菌感染治疗方面具有重大潜力的主题，包括(1)促进抗生素对病原体的定位，(2)调节药物-病原体相互作用以对抗抗生素耐药性，以及(3)实现新的抗毒方法以实现“无药物”抗菌活性。在每个领域，我们强调了为当地应用量身定制的创新抗菌策略，并回顾了治疗细菌感染的进展。
Despite the wide success of antibiotics in modern medicine, the treatment of bacterial infections still faces critical challenges, especially due to the rapid emergence of antibiotic resistance. As a result, local antimicrobial treatment aimed at enhancing drug concentration at the site of infection while avoiding systemic exposure is becoming increasingly attractive, as it may alleviate resistance development. Meanwhile, therapeutic nanoparticles, especially liposomes, polymeric nanoparticles, dendrimers, and inorganic nanoparticles, are gaining traction to improve the therapeutic efficacy with many applications specifically focused on local antimicrobial treatment. This review highlights topics where nanoparticle-based strategies hold significant potential to advance treatment against local bacterial infections, including (1) promoting antibiotic localization to the pathogen, (2) modulating drug-pathogen interaction against antibiotic resistance, and (3) enabling novel anti-virulence approaches for ‘drug-free’ antimicrobial activity. In each area, we highlight the innovative antimicrobial strategies tailored for local applications and review the progress made for the treatment of bacterial infections.
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影响因子：
17.1
作者：
Choi, Seok Ki;Myc, Andrzej;Baker, James R., Jr.
通讯作者：
Baker, James R., Jr.
影响因子：
16.1
作者：
Bayramov DF;Neff JA
通讯作者：
Neff JA
影响因子：
5.4
作者：
Barczak, Amy K.;Hung, Deborah T.
通讯作者：
Hung, Deborah T.
影响因子：
2.3
作者：
Baietto L;Corcione S;Pacini G;Perri GD;D'Avolio A;De Rosa FG
通讯作者：
De Rosa FG
影响因子：
5.2
作者：
BARZA, M;CUCHURAL, G
通讯作者：
CUCHURAL, G